Percutaneous penetration enhancers. (2006)

• Record Type: Book
• Further Information: Note: Edited by Eric W. Smith, Howard I. Maibach.
• Other Names: Smith, Eric W; Maibach, Howard I
• Contents: Front cover; Contents; Contributors; Editors; Preface; INTRODUCTION; Chapter 1; Penetration Enhancer Classification; CONTENTS; Introduction; Drug Transport Routes through Human Skin; Enhancing Transdermal Drug Delivery; References; Chapter 2; Structure-Activity Relationship of Chemical Penetration Enhancers; CONTENTS; Introduction; Fatty Acids; Fatty Alcohols; Terpenes; Pyrrolidones; Surfactants; Conclusions; References; Chapter 3; Quantitative Structure- Enhancement Relationship and the Microenvironment of the Enhancer Site of Action; CONTENTS; Introduction; Methods Quantitative Structure-Enhancement Relationships Based on Aqueous Concentrations of the EnhancerQuantitative Structure-Enhancement Relationship Based on Enhancer Concentrations in the Stratum Corneum Intercellular Lipids; Microenvironment of the Site of Enhancer Action; Transdermal Drug Delivery; Acknowledgment; References; Chapter 4; The Role of Prodrugs in Penetration Enhancement; CONTENTS; Push versus Pull Mechanisms for Penetration Enhancers; Basis for Prodrugs as Penetration Enhancers; Acyl versus Soft Alkyl Promoieties; Mechanisms for Penetration Enhancement Table 4.1 Prodrugs of 5-FluorouracilTable 4.2 Prodrugs of Levonorgestrel; Table 4.3 Prodrugs of Indomethacin and Naproxen; Table 4.4 Prodrugs of Naproxen, Ketoprofen, and Diclofenac; Conclusion; References; VEHICLE EFFECTS IN PENETRATION ENHANCEMENT; Chapter 5; Penetration Enhancement by Skin Hydration; CONTENTS; Introduction; Stratum Corneum Hydration by Occlusion; Stratum Corneum Hydration by Exogenous Chemicals; Conclusions; References; Chapter 6; Enhancement of Delivery with Transdermal Sprays; CONTENTS; Introduction; Enhancement of Delivery of the Dose to the Skin Enhancement of Delivery into the Stratum CorneumEnhancement of Permeation through Skin; Enhancement of Bioavailability; Characteristics of Solvents and Enhancers Required for Metered Dose Spray Delivery; References; Chapter 7; Hydrogel Vehicles for Hydrophilic Compounds; CONTENTS; Hydrogels; Applications of Hydrogels and Patches in Transdermal Delivery; Conclusions; References; Chapter 8; Enhanced Skin Permeation Using Ethosomes; CONTENTS; Introduction; Definition, Structure, and the Main Properties of Ethosomes; Mechanism of Skin Permeation Enhancement by Means of Ethosomes Various Aspects of Ethosomal Delivery SystemSummary; Acknowledgment; References; Chapter 9; Microemulsions in Topical Drug Delivery; CONTENTS; Introduction; Microemulsions in Topical Drug Delivery; Conclusions; References; Chapter 10; Nanoparticles as Carriers for Enhanced Skin Penetration; CONTENTS; Introduction; Microparticles for Enhancing Skin Penetration; Nanoparticles for Enhancing Skin Penetration; PNBCA Nanocapsules as a Carrier for Enhanced Skin Penetration of Indomethacin
• Edition: 2nd ed
• Publisher Details: Boca Raton : CRC/Taylor & Francis
• Publication Date: 2006
• Extent: 1 online resource (x, 432 pages), illustrations
• Subjects: 615/.6; Transdermal medication; Skin absorption; Skin absorption -- Drug effects; MEDICAL -- Pharmacology; Skin absorption; Transdermal medication; Skin Absorption -- drug effects; Administration, Cutaneous; Electronic books; Electronic books
• Languages: English
• ISBNs: 1420039202; 9781420039207
• Related ISBNs: 9780849321528; 0849321522
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.