Clinical trials in oncology. (©2003)

• Record Type: Book
• Further Information: Note: Stephanie Green, Jacqueline Benedetti, John Crowley.
• Other Names: Green, Stephanie (Stephanie Janet); Benedetti, Jacqueline; Crowley, John, 1946-
• Contents: INTRODUCTION; A Brief History of Clinical Trials; The Southwest Oncology Group; Example Trials; The Reason for the Book; STATISTICAL CONCEPTS; Introduction; The Phase II Trial-Estimation; The Phase III Trial-Hypothesis Testing; The Proportional Hazards Model; Sample Size Calculations; Concluding Remarks; THE DESIGN OF CLINICAL TRIALS; Introduction; Endpoints; Phase I Trials; Phase II Trials; Phase III Trials; Conclusion; MULTI-ARM TRIALS; Introduction; Types of Multi-Arm Trials; Significance Level; Power; Interaction; Other Model Assumptions; To Screen or Not to Screen; Timing of Randomization; Conclusion; INTERIM ANALYSIS AND DATA MONITORING COMMITTEES; Planned Interim Analysis; Data Monitoring Committees: Rationale and Responsibilities; Monitoring Committees: Composition; Examples; Concluding Remarks; DATA MANAGEMENT AND QUALITY CONTROL; Introduction: Why Worry?; Protocol Development; Data Collection; Protocol Management and Evaluation; Quality Assurance Audits; Training; Data Base Management; Conclusion; Appendix: Examples; REPORTING OF RESULTS; Timing of Report; Required Information; Analyses; Conclusion; PITFALLS; Introduction; Historical Controls; Competing Risks; Outcome by Outcome Analyses; Subset Analyses; Surrogate Endpoints; EXPLORATORY ANALYSES; Introduction; Some Background and Notation; Identification of Prognostic Factors; Forming Prognostic Groups; Analysis of Microarray Data; Meta-Analysis; Concluding Remarks; SUMMARY AND CONCLUSIONS
• Edition: 2nd ed
• Publisher Details: Boca Raton, Fla : Chapman & Hall
• Publication Date: 2003
• Copyright Date: 2003
• Extent: 1 online resource (xi, 265 pages), illustrations
• Subjects: 616.99/4/00727; Cancer -- Research -- Statistical methods; Clinical trials; Clinical Trials as Topic -- standards; Neoplasms -- therapy; Clinical Trials as Topic; Data Interpretation, Statistical; MEDICAL -- Oncology; HEALTH & FITNESS -- Diseases -- Cancer; Cancer -- Research -- Statistical methods; Clinical trials; Statistics; Electronic books
• Languages: English
• ISBNs: 1420035304; 9781420035308
• Related ISBNs: 1584883022; 9781584883029
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.