Handbook of assay development in drug discovery. (©2006)

• Record Type: Book
• Further Information: Note: Edited by Lisa K. Minor.
• Other Names: Minor, Lisa
• Contents: Protein Kinases in Drug Discovery: Rationale, Success, and Challenge; Dana L. Johnson and Jan L. Sechler ; An Introduction to the Protein Tyrosine Phosphatase Gene Family and Screening Assay Development; Dominique Perrin and Rob Hooft van Huijsduijnen ; Time-Resolved Fluorescence Based Assays for Kinases; Zhuyin Li and Tina Garyantes ; Development of High-throughput Screening Assays in Scintillating Microplates (FlashPlates) to Identify Inhibitors of Kinase Activity; Stewart Emanual ; Development of High-Throughput Screening Assays for Kinase Drug Targets using AlphaScreen™ Technology; D. Wenham, C. Illy, J.A. St. Pierre, and N. Bouchard ; Homogeneous High-Throughput Screening (HTS) Assays for Serine/Threonine Kinases Using ß-Galactosidase Enzyme Fragment Complementation; I. Vainshtein, T. Naqvi, A. Lim, R. Rouhani, L. Kauffman, R. Singh, and R.M. Eglen ; IMAP Assays for Assaying Protein Kinases; R. Sportsman ; A Homogenous, Luminescent, High-Throughput, Versatile Assay for a Wide Range of Kinases; S.A. Goueli, K. Hsiao, and B. Bulleit ; Proteases as Drug Targets; R.L. Thurmond and J.P. Edwards ; A Comparison of Homogeneous Bioluminescent and Fluorescent Methods for Protease Assays; M. O’Brien ; Scintillation Proximity Assay (SPA) Receptor Binding Assays; J.R. Cook, R. Graves, K. Lowitz, M.J. Price-Jones, J.A. Berry and K.T. Hughes ; Radioligand Binding Filtration Assay: Full Automation; S.K.F. Wong ; Nuclear Receptors As Drug Targets; P.D. Pelton ; Nuclear Receptor Scintillation Proximity Assays; D. Powell and M.J. Price-Jones ; Homogenous Assay Development for Nuclear Receptor Using the AlphaScreen Technology; N. Rouleau and R. Boss é; Development of Nuclear Receptor Homogenous Assay Using the Lance Technology; N. Rouleau, P. Hurskainen, I. Hemmil ä and R. Boss é; The Emerging Role of Cell-based Assays in Discovery; R. Garippa ; The Preparation of Cells for High-Content Screening; A. Hoffman ; The Evolution of cAMP Assays; P. Kasila and H. Harney ; A Homogenous Fluorescent Polariaiton assay for Inositol 1, 4, 5-Trisphoshpate (Ins P3 ); P. Fung, R. Singh, L. Kauffman, R.M. Eglen and T. Naqvi ; Scintillation Proximity Assay of Inositol Phosphates; W. Zheng and P. Brandish ; Measuring Calcium Mobilization with Gq -Coupled GPCRs Using the Fluorometric Imaging Plate Reader (FLIPR); J. Dunlop, Y. Zhang, R. Ring and D. Kowal ; Development of FLIPR-Based HTS Assay for Gi -Coupled GPCRs; C. Chen, C. Smith, L. Minor, and B. Damiano ; Aurora Assays; P, Kunapuli ; Membrane Potential Based Assays for Ion Channels and Electrogenic Transporters; Q, Lü, S, Lin, and J, Dunlop ; Reporter Gene Assays for Drug Discovery; K.A. Houck, W.P. Bocchinfuso, M.S. Dowless, and K.M. Borchert ; mRNA Detection from Cells Using Quantigene® Branched DNA Technology; L. Minor ; Homogeneous Miltiwell Assays for Measuring Cell Viability, Cytotoxicity and Apoptosis; Terry Riss, R.A. Moravec, M.A. O’Brien, E.M. Hawkins, and A. Niles ; Development of Image-Bases Assays for Drug Discovery; S.M. Catalano ; GPCR Internalization Measured by Image Analysis; R. Graves, M.J. Francis, L. Smith, J.R. Cook, and E.J. Adie ; TRANSFLUOR®, a Universal Cell-Based Assay for Screening G-Protein Coupled Receptors; R. Oakley C.L. Cowan, C.C. Hudson, and C.R. Loomis
• Publisher Details: Boca Raton : CRC/Taylor & Francis
• Publication Date: 2006
• Copyright Date: 2006
• Extent: 1 online resource (464 pages), illustrations (some color)
• Subjects: 615/.19; Drug development -- Handbooks, manuals, etc; Drugs -- Research -- Handbooks, manuals, etc; Drugs -- Design -- Handbooks, manuals, etc; Drug delivery systems -- Methods -- Laboratory manuals; Pharmaceutical preparations -- Analysis -- Laboratory manuals; Médicaments -- Développement -- Guides, manuels, etc; Médicaments -- Recherche -- Guides, manuels, etc; Médicaments -- Conception -- Guides, manuels, etc; MEDICAL -- Drug Guides; MEDICAL -- Pharmacology; MEDICAL -- Pharmacy; MEDICAL -- Nursing -- Pharmacology; Drug development; Drugs -- Design; Drugs -- Research; Drug Delivery Systems -- methods; Pharmaceutical Preparations -- analysis; Electronic books; Handbooks and manuals
• Languages: English
• ISBNs: 9781420015706; 1420015702
• Related ISBNs: 1574444719; 9781574444711
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.