Prions : the new biology of proteins /: the new biology of proteins. (2005)

• Record Type: Book
• Further Information: Note: Claudio Soto.
• Other Names: Dr, Soto, Claudio
• Contents: Each chapter ends with a concluding summation and references; Human and animal diseases: clinical symptoms, epidemiology, and neuropathology ; Human diseases; Animal diseases; Variant CJD; Neuropathology; The infectious agent and the prion hypothesis ; Hypothesis for the infectious agent; Evidence supporting the prion hypothesis; Criticisms of the prion hypothesis; In vitro generation of prions; The prion protein: structure, conversion, and ; mechanism of propagation ; Structural features of the cellular and scrapie prion protein isoforms; Molecular mechanism of PrPC to PrPSc conversion; Other factors involved in PrP conversion; Peptide models used to understand PrP structure and conversion; Cell biology, genetic and putative function of the normal prion protein; Cellular biology of the normal prion protein; A signaling role for the prion protein?; PrP ligands indicate a potential role in apoptosis; A putative role of PrP in copper metabolism; PrP knockout animals and doppel; Prion strains, species barriers, and multiple ; conformations of the prion protein ; Prion strains; Species barrier; Multiple conformations of PrP; From the mouth to the brain ; Prions in the gastrointestinal tract; The immune-system connection; From the lymphoid organs to the brain: peripheral nerves or blood–brain barrier?; Neurodegeneration in prion diseases ; Characteristics of brain degeneration; Is PrP the cause of TSE neurodegeneration?; Mechanism of neuronal apoptosis; Neuronal apoptosis in TSEs involves the ER-stress pathway; A role for the proteasome in TSE pathogenesis?; The diagnosis problem and current tests ; Importance of early diagnosis; Difficulties of diagnosis; Current status of TSE diagnosis in humans; Postmortem detection of BSE in cattle; The need for detection of PrP in blood; Novel approaches under development for premortem early diagnosis; Spectroscopic techniques ; Conformational antibodies; PrP concentration by binding to specific ligands; PrP amplification; Therapeutic approaches ; Targets for TSE therapy; Compounds under development for TSE treatment; Immunization approach ; Cyclic amplification of prion protein misfolding: rationale, applications, and perspectives ; The rationale behind PMCA ; Applications of PMCA in prion diagnosis ; In vitro generation of infectious prions by PMCA; Application of PMCA to understand the prion replication process ; Other diseases of protein misfolding ; Protein misfolding and disease; Structural determinants of misfolding and aggregation; Mechanism and driving forces in protein misfolding and aggregation; Kinetics and intermediates of misfolding and aggregation; Interactions between misfolded proteins; Prions: a common phenomenon in biology? ; The yeast prions; The inherent infectious nature of misfolded aggregates; Why are protein misfolding disorders other than TSE not infectious?; How common is the prion phenomenon in nature?
• Publisher Details: Place of publication not identified : CRC Press
• Publication Date: 2005
• Extent: 1 online resource, illustrations
• Subjects: 616.830421; Prion diseases; Prion diseases in animals; Biotechnology
• Languages: English
• ISBNs: 9781420040128
• Related ISBNs: 142004012X
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.