Introduction to randomized controlled clinical trials. (©2006)

• Record Type: Book
• Uniform Title: CRC Press Online.
• Further Information: Note: John N.S. Matthews.
• Other Names: Matthews, J. N. S; CRC Press.
• Contents: WHAT IS A RANDOMIZED CONTROLLED TRIAL? -- Definition and Key Features -- Historical Context and the Nature of RCTS -- Structure and Justification of RCTs -- Exercises -- BIAS -- What is meant by bias in RCTs? -- Types of Bias -- Exercises -- HOW MANY PATIENTS DO I NEED? -- Criteria for Sample Size Calculations -- Hypothesis Tests -- Sample Size for a Normally Distributed Variable -- Sample Size for a Binary Variable -- General Remarks About Sample Size Calculations -- Exercises -- METHODS OF ALLOCATION -- Simple Randomization -- Random Permuted Blocks -- Biased Coin Designs and Urn Schemes -- Unequal Randomization -- Stratification -- Minimization -- Exercises -- ASSESSMENT, BLINDING AND PLACEBOS -- Double and Single Blindness -- Placebos -- Practical Considerations -- Exercises -- ANALYSIS OF RESULTS -- Example -- Use of Confidence Intervals -- Baselines: Uses and Abuses -- Analysis of Covariance -- Exercises -- FURTHER ANALYSIS: BINARY AND SURVIVAL DATA -- Binary Data: An Example and a Statistical Model -- Point Estimates and Hypothesis Tests -- Interval Estimates for the Binary Case -- Adjusting Binary Outcomes for Baseline Observations -- Survival Analysis -- Analyses Using Randomization Models -- Exercises -- MONITORING ACCUMULATING DATA -- Motivation and Problems with Repeated Analysis of Data -- Sequential and Group-Sequential Methods -- Other Approaches to Accumulating Data -- Data Monitoring Committees -- Exercises -- SUBGROUPS AND MULTIPLE OUTCOMES -- The Role of Sub-groups in Randomized Clinical Trials -- Methods for Comparing Sub-groups -- Methods of Selecting Sub-groups -- Qualitative Interactions -- Multiple outcomes -- Correction of P-values -- Some Alternative Methods for Multiple Outcomes -- Exercises -- PROTOCOLS AND PROTOCOL DEVIATIONS -- Protocols: Their Nature and Role -- Protocol Deviation -- Analysis by Intention-to-Treat -- Exercises. SOME SPECIAL DESIGNS: CROSSOVERS, EQUIVALENCE AND CLUSTERS -- Crossover Trials and Parallel Group Trials -- The AB/BA Design -- Analysis of AB/BA Design for Continuous Outcomes -- The Issue of Carryover -- Equivalence Trials -- Cluster Randomized Trials -- Exercises -- META-ANALYSES OF CLINICAL TRIALS -- What Are Meta-Analyses and Why Are They Needed? -- Some Methodology for Meta-Analysis -- Some Graphical Methods for Meta-Analysis -- Some General Issues in Meta-Analysis -- Exercises -- FURTHER READING -- SOLUTIONS TO EXERCISES -- REFERENCES.
• Edition: 2nd ed
• Publisher Details: Boca Raton, Fla : CRC Press
• Publication Date: 2006
• Copyright Date: 2006
• Extent: 1 online resource (283 pages), illustrations
• Subjects: 610.72/4; Clinical trials -- Statistical methods; Clinical trials -- Statistical methods; Études cliniques -- Méthodes statistiques; Clinical trials; Statistische methoden; Klinisk prövning -- statistiska metoder; Randomized Controlled Trials as Topic; Research Design; Statistics; Electronic books
• Languages: English
• ISBNs: 1584886242; 9781584886242; 9781420011302; 1420011308
• Notes: Note: Includes bibliographical references (pages 269-272) and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.