Inhibitors of cyclin-dependent kinases as anti-tumor agents. (©2007)

• Record Type: Book
• Further Information: Note: Edited by Paul J. Smith, Eddy W. Yue.
• Other Names: Smith, Paul J (Paul James), 1953-; Yue, Eddy W
• Contents: INTEGRATION OF CELL CYCLE CONTROL PATHWAYS AND THE OPPORTUNITIES FOR TARGETING ; Cell Cycle Dynamics and the Challenges for CDK Targeting; Paul J. Smith, Emeline Furon, and Rachel J. Errington ; Functional Regulation of CIP/KIP CDK Inhibitors; Mong-Hong Lee and Ruiying Zhao ; Mouse Models to Study the In Vivo Function of Cyclin-Dependent Kinases in Normal Homeostasis and Tumor Development; Marcos Malumbres, Pierre Dubus, and Sagrario Ortega ; Cyclin-Dependent Kinase Inhibitors and Vascular Disease; Martin F. Crook and Manfred Boehm ; CDK INHIBITORS: TARGETS AND THEIR EVALUATION ; Evaluation of CDK Inhibitor Selectivity: From Affinity Chromatography to Yeast Genetics; Stéphane Bach, Marc Blondel, and Laurent Meijer ; Development of CDK Inhibitors as Anticancer Agents: From Rational Design to CDK4-Specific Inhibition; Sachin Mahale and Bhabatosh Chaudhuri ; Three-Dimensional Structures of Cyclin-Dependent Kinases and Their Inhibitor Complexes; Ursula Schulze-Gahmen and Sung-Hou Kim ; CDK INHIBITORS: CHEMISTRY FOCUS ; Cyclin-Dependent Kinase Small Molecule Modulators for Cancer Therapy; Adrian M. Senderowicz ; (R )-Roscovitine (CYC202, Seliciclib); Laurent Meijer, Karima Bettayeb, and Hervé Galons ; Development, Selectivity, and Application of Paullones, a Family of CDK Inhibitors; Conrad Kunick, Thomas Lemcke, and Laurent Meijer ; Discovery of BMS-387032, a Potent Cyclin-Dependent Kinase Inhibitor in Clinical Development; John T. Hunt ; Oxindole Inhibitors of Cyclin-Dependent Kinases as Antitumor Agents; Philip A. Harris ; Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors; David J. Carini, Catherine R. Burton, and Steven P. Seitz ; Development of Indolocarbazoles as Cyclin D1/CDK4 Inhibitors; Guoxin Zhu ; Pyrazoles as Efficient Adenine-Mimetic Heterocycles for the Discovery of CDK Inhibitors; Paolo Pevarello and Anna Vulpetti ; Pyrazolo [3, 4-d ] pyrimidin-4-ones: Exploring the Structural Determinants of Potency and Selectivity in Cyclin-Dependent Kinase Inhibition; Jay A. Markwalder and Steven P. Seitz ; THERAPEUTIC PERSPECTIVE ; Cyclin-Dependent Kinase Inhibitors and Combination Therapy: Experimental and Clinical Status; Lloyd R. Kelland ; CDK Inhibitors as Anticancer Agents: Perspectives for the Future; Jayalakshmi Sridhar, Nagarajan Pattabiraman, Eliot M. Rosen, ; and Richard G. Pestell ; INDEX
• Publisher Details: Boca Raton : CRC/Taylor & Francis
• Publication Date: 2007
• Copyright Date: 2007
• Extent: 1 online resource (448 pages, [8] pages of plates), illustrations (some color)
• Subjects: 616.99/407; Cyclin-dependent kinases -- Inhibitors; Cyclin-dependent kinases -- Inhibitors -- Therapeutic use -- Testing; Cancer -- Chemotherapy; Cyclin-Dependent Kinases -- antagonists & inhibitors; Cyclin-Dependent Kinases -- therapeutic use; Antineoplastic Agents -- therapeutic use; Drug Therapy -- methods; MEDICAL -- Oncology; HEALTH & FITNESS -- Diseases -- Cancer; Farmacoterapia del cáncer; Electronic books
• Languages: English
• ISBNs: 9781420005400; 1420005405
• Related ISBNs: 0849337747; 9780849337741
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.