Percutaneous absorption : drugs, cosmetics, mechanisms, methodology /: drugs, cosmetics, mechanisms, methodology. (2005)

• Record Type: Book
• Further Information: Note: Edited by Robert L. Bronaugh, Howard I. Maibach.
• Other Names: Bronaugh, Robert L, 1942-; Maibach, Howard I
• Contents: Front cover; Preface; Contents; Contributors; 1; Mathematical Models in Percutaneous Absorption; I. IN VITRO SKIN DIFFUSION MODELS IN PERCUTANEOUS ABSORPTION; A. In Vitro Skin Permeability Studies with a Constant Donor Concentration and Sink Receptor Conditions; B. Amount and Flux-Time Profiles on Removing the Donor Phase After Reaching the Steady State for Conditions Described in sec. I.A; C. In Vitro Permeability Studies with a Constant Donor Concentration and Finite Receptor Volume. D. In Vitro Permeability Studies with a Constant Donor Concentration or Defined Input Flux and Finite Clearance of Solute from the EpidermisE. In Vitro Skin Permeability Studies with Finite Donor Volume and Receptor Sink Conditions; F. In Vitro Permeability Studies with a Finite Donor Volume and a Finite Clearance from the Epidermis into the Receptor; G. In Vitro Skin Permeability Studies with Diffusion Limited Finite Donor and Sink Receptor Conditions; H. In Vitro Permeability Studies with Two-Layer Diffusion Limitations in Transport; I. Desorption; J. SC Heterogeneity. II. RELEASE PROFILES FROM TOPICAL PRODUCTSA. Diffusion-Controlled Release; B. Release of a Suspended Drug by Diffusion; III. COMPARTMENTAL MODELS AS AN ALTERNATIVE TO DIFFUSION MODELS IN PERCUTANEOUS ABSORPTION; IV. OTHER PROCESSES AFFECTING IN VITRO PERCUTANEOUS ABSORPTION A. Concentration-Dependent Diffusive Transport Processes; B. Bioconversion/Metabolism of Solutes in the Skin; C. Solute-Vehicle, Vehicle-Skin, and Solute-Skin Interactions; D. Effect of Surface Loss Through Processes Such as Evaporation and Adsorption to Skin Surface; E. Shunt Transport; F. Reservoir Effect. V. SIMPLE IN VIVO MODELS IN PERCUTANEOUS ABSORPTION A. Compartmental Pharmacokinetic ModelsB. Diffusion Pharmacokinetic Models; C. Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Models; D. Deconvolution Analysis in Pharmacokinetic Modeling; E. Penetration into Tissues Underlying Topical Application Site; F. Pharmacodynamic Modeling; VI. MODELING WITH FACILITATED TRANSDERMAL DELIVERY A. Iontophoresis; B. Sonophoresis; VII. PRACTICAL ISSUES IN APPLYING MATHEMATICAL MODELS TO PERCUTANEOUS ABSORPTION DATA; VIII. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; 2. Skin Metabolism During In Vitro Percutaneous AbsorptionI. INTRODUCTION; II. SKIN VIABILITY; III. SKIN METABOLISM; REFERENCES; 3; Cutaneous Metabolism of Xenobiotics; I. INTRODUCTION; II. XENOBIOTIC-METABOLIZING ENZYMES; III. PHASE I METABOLISM: CYTOCHROME P-450 MONOOXYGENASES; A. Isoenzymes of Cytochrome P-450; IV. PHASE II METABOLISM; A. Transferases; V. EXAMPLES OF XENOBIOTIC METABOLISM A. Corticosteroids; B. Beta-Adrenoceptor Antagonists; C. Topical Nitrates; D. Theophylline; VI. METABOLISM OF ENVIRONMENTAL XENOBIOTICS; A. Polycyclic Aromatic Hydrocarbons; B. Pesticides.
• Edition: 4th ed
• Publisher Details: Boca Raton : Taylor & Francis
• Publication Date: 2005
• Extent: 1 online resource (xxvi, 878 pages), illustrations
• Subjects: 615/.6; Transdermal medication; Skin absorption; Skin -- Permeability; Skin Absorption; Skin -- Permeability; Skin absorption; Transdermal medication; Médicaments -- Administration par voie transdermique; Absorption cutanée; Peau -- Perméabilité; MEDICAL -- Pharmacology; Skin absorption; Skin -- Permeability; Transdermal medication; Electronic books; Electronic books
• Languages: English
• ISBNs: 9780849359033; 0849359031
• Related ISBNs: 9781574448696; 1574448692
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.