Drug delivery to the oral cavity : molecules to market /: molecules to market. (2005)

• Record Type: Book
• Further Information: Note: [editors] Tapash K. Ghosh, William R. Pfister.
• Other Names: Ghosh, Tapash K; Pfister, William R
• Contents: Front cover; Contents; Preface; The Editors; Contributors; Dedication; 1; Intraoral Delivery Systems: An Overview, Current Status, and Future Trends; I. Introduction; II. Intraoral Drug Delivery; A. Product Market; B. Anatomy of Oral Cavity; C. Intraoral Drug Delivery; D. Intraoral Drug Absorption; III. Overview: Intraoral Delivery Systems; A. Routes of Administration; B. Classification of Intraoral Dosage Forms; 1. Quick-Dissolving Delivery Systems; 2. Slow-Dissolving Delivery Systems; 3. Nondissolving Delivery Systems; IV. Current Status: Intraoral Drug Delivery. A. Quick-Dissolving Delivery Systems1. Lyophilized Wafers; 2. Orally Disintegrating Tablets; 3. Thin Films and Strips; 4. Quick-Dissolve Products; 5. Intraoral Liquid Delivery Technology; B. Slow-Dissolving Delivery Systems; 1. Buccal Tablets; 2. Slow-Dissolve Products; C. Nondissolving Delivery Systems; 1. Medicated Chewing Gums; 2. Buccal Patches; V. Intraoral Drug Delivery Excipients; VI. Intraoral Dosage Form Barrier Packaging; VII. Future Trends: Intraoral Drug Delivery; A. Patent Domain; B. Products in Development; VII. Summary; Acknowledgments; References; 2. Preclinical Assessment of Oral Mucosal Drug Delivery SystemsI. Introduction; II. Anatomical and Physiological Details of the Oral Mucosa; A. Tissue Types and Characteristics; B. Generalized Structure of Oral Mucosa and Its Barrier Function; 1. Epithelium; 2. Basement Membrane and Connective Tissue; 3. Salivary Flow; III. Evaluation of Mucosal Permeation; A. In Vitro Mucosal Permeation Techniques; B. In Vivo Methods; C. Animal Models for Permeability Measurement; IV. Evaluation of Mucoadhesion; A. In Vitro Assessment of Mucoadhesion; 1. Methods Based on Measurement of Adhesion Strength. 2. Methods Based on Measurement of Shear Strength3. Bioadhesion Test Using Nonbiological Substances; 4. Fluorescent Probe Method; 5. In Situ Method; 6. Organ Culture Technique; 7. Ligand Receptor Binding Method; 8. Flow Channel Methods; 9. Falling Liquid Film Method; 10. Colloidal Gold Staining Method; 11. Thumb Test; 12. Viscometric Method; B. In Vivo Assessment of Mucoadhesion; V. Oral Mucosal Drug Delivery Systems; A. Bioadhesive Tablets; B. Bioadhesive Patches; C. Phase Change Polymers; VI. Product Safety; VII. Summary; References; 3. Modulation of Oral Transmucosal Permeability: Permeation EnhancersI. Introduction; II. Oral Mucosal Drug Delivery; III. Anatomy of the Oral Cavity; A. Buccal Epithelium; B. Lamina Propria; C. Submucosa; D. Biochemical Structure; IV. Physiology and Environment of the Oral cavity; V. Modes of Transport across Buccal Mucosa; A. Transcellular Pathway; B. Paracellular Pathway; C. Active (Carrier-Mediated) Transport System; VI. Kinetics of Transport Mechanisms; A. Paracellular Pathway; B. Transcellular Pathway; C. Intraoral Drug Absorption and Transport Pathways; VII. Permeability of Buccal Mucosa.
• Publisher Details: Boca Raton : Taylor & Francis
• Publication Date: 2005
• Extent: 1 online resource (xix, 413 pages), illustrations
• Subjects: 615/.6; Oral medication; Oral mucosa; Oral medication; Oral mucosa; Oral medication; Oral mucosa; Administration, Oral; Drug Delivery Systems -- methods; Mouth Mucosa -- drug effects; Mouth Mucosa -- metabolism; Electronic books; Electronic books
• Languages: English
• ISBNs: 0849398517; 9780849398513; 9780824782931; 0824782933
• Related ISBNs: 0824782933
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.