Modeling in the neurosciences : from biological systems to neuromimetic robotics /: from biological systems to neuromimetic robotics. (2005)

• Record Type: Book
• Further Information: Note: Edited by G.N. Reeke [and others].
• Other Names: Reeke, G. N (George N.), 1943-
• Contents: Front cover; Contents; Preface to the Second Edition; Contributors; Foreword; About the Editors; 1 Introduction to Modeling in the Neurosciences; 2 Patterns of Genetic Interactions: Analysis of mRNA Levels from cDNA Microarrays; CONTENTS; 2.1 INTRODUCTION 2.1.1 Biological Organisms are Complex Systems; 2.1.2 Genes Interact withEac hOth er; 2.2 GENETIC INTERACTION; 2.2.1 Network Topologies; 2.2.2 Genomic Networks; 2.3 GENETIC NETWORKS; 2.4 INTEGRATIVE MODELING APPROACH; 2.4.1 The General Model; 2.4.2 Five Models of Genetic Networks. 2.4.3 EachModel Generates mRNA Levels with a Characteristic PDF2.5 BIOLOGICAL DATA; 2.6 SUMMARY; ACKNOWLEDGMENTS; PROBLEMS; APPENDIX: MULTI-HISTOGRAM ALGORITHM FOR DETERMINING THE PDF; 3 Calcium Signaling in Dendritic Spines; CONTENTS; 3.1 INTRODUCTION; 3.2 FIRST-GENERATION DENDRITIC-SPINE CALCIUM MODELS; 3.2.1 Calcium Diffusion; 3.2.2 Calcium Buffering; 3.2.3 Calcium Pumps; 3.2.4 Calcium Influx; 3.2.5 Calcium from Intracellular Stores; 3.2.6 Summary; 3.3 INSIGHTS; 3.3.1 SpinesCompartmentalize Calcium Concentration Changes; 3.3.2 SpinesAmplify Calcium Concentration Changes. 3.3.3 Spine-Head Calcium (or CaMCa4) Concentration isa Good Predictor of LTP3.3.4 Spine Shape Playsan Important Role in the Ability of a Spine to Concentrate Calcium; 3.4 ISSUES; 3.4.1 Calcium Pumps; 3.4.2 Calcium Buffers; 3.4.3 Calcium Source; 3.5 IMAGING STUDIES TEST MODEL PREDICTIONS; 3.5.1 SpinesCompartmentalize Calcium Concentration Changes; 3.5.2 Importance of Spine Geometry; 3.6 INSIGHTS; 3.6.1 Sourcesof Calcium in Spines; 3.6.2 Calcium Extrusion via Pumps; 3.6.3 Calcium Buffersin Spines; 3.7 ADDITIONAL INSIGHTS; 3.7.1 Spine Motility. 3.7.2 Coincidence Detection with Backpropagating Action Potentials3.8 SECOND-GENERATION SPINE MODELS: REACTIONS LEADING; 3.8.1 Modeling CaMKII Activation isComplicated; 3.8.2 Characteristics of Second-Generation Models; 3.9 INSIGHTS; 3.9.1 Frequency Dependence of CaMKII Activation; 3.9.2 Different Stagesof CaMKII Activation; 3.9.3 CaMKII Activation asa Bistable Molecular Switch; 3.9.4 CaMKII and Bidirectional Plasticity; 3.9.5 CaMKII Activation and Spine Shape; 3.9.6 ModelsPr edict the Need for Repetition of Short TetanusT rains; 3.10 FUTURE PERSPECTIVES; 3.11 SUMMARY; PROBLEMS. APPENDIX 1. TRANSLATING BIOCHEMICAL REACTION EQUATIONS TO DIFFERENTIAL EQUATIONSAPPENDIX 2. STOCHASTIC RATE TRANSITIONS; APPENDIX 3. USE OF MICHAELIS-MENTEN KINETICS IN DEPHOSPHORYLATION REACTIONS; 4 Physiological and Statistical Approaches to Modeling of Synaptic Responses; CONTENTS; 4.1 INTRODUCTION 4.1.1 Modeling Synaptic Function in the CNS; 4.1.2 Complexity Introduced by Synaptic Heterogeneity and Plasticity; 4.1.3 Complexity Associated with Physiological Recordings; 4.1.4 Classical Statistical Models; 4.2 NONTRADITIONAL MODELS.
• Edition: Second edition
• Publisher Details: Boca Raton, FL : Taylor & Francis
• Publication Date: 2005
• Extent: 1 online resource (xvii, 711 pages), illustrations, portraits
• Subjects: 573.860113; Neurons -- Computer simulation; Neurons -- Mathematical models; Neural networks (Neurobiology); Computational neuroscience; Models, Neurological; Computer Simulation; Neurons -- physiology; Neurosciences -- methods; Computer simulation; Neurosciences -- Methods; Neurons -- Physiology; SOCIAL SCIENCE -- Anthropology -- Physical; Computational neuroscience; Neural networks (Neurobiology); Neurons -- Computer simulation; Neurons -- Mathematical models; Electronic books; Electronic books
• Languages: English
• ISBNs: 0203390970; 9780203390979; 9781420023343; 1420023349
• Related ISBNs: 0415328683; 1420023349; 9780415328685
• Notes: Note: Includes bibliographical references (pages 647-704) and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.