Structural and mechanistic enzymology. (2017)

• Record Type: Book
• Further Information: Note: Edited by Tatyana Karabencheva-Christova.
• Editors: Karabencheva-Christova, Tatyana
• Contents: Title page; Table of Contents; Copyright; Contributors; Preface; Chapter One: Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies; Abstract; 1 Matrix Metalloproteinases; 2 MD Simulation Approaches; 3 MD Simulation of the Collagen Triple Helix; 4 MD Simulation of the MMP Cleavage Site in Collagen; 5 MD Consideration of Water Surrounding Collagen; 6 MD of MMP-1 or MMP-8 Interaction With Collagen; 7 MD of MMP-2 Interaction With Collagen; 8 Mechanism of Collagenolysis; Acknowledgments Chapter Two: Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor DesignAbstract; 1 Introduction; 2 Computational Methods; 3 Puckering of Carbohydrate Structures; 4 Identification of Catalytically Competent Protonation States of Key Residues; 5 Clarification of Catalytic Mechanisms; 6 Transition-State Analogues as Inhibitors of CAZymes; 7 Conclusions and Future Directions; Acknowledgments; Chapter Three: Computational Biochemistry-Enzyme Mechanisms Explored; Abstract; 1 Introduction; 2 Structural Models 3 Calculating Enzymatic Mechanisms4 Going Beyond the Exploration of the Reaction Paths; Chapter Four: A Paradigm for C-H Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase; Abstract; 1 Introduction; 2 Structure and Function Within the MR Subgroup; 3 MR Catalysis: An Uphill Battle; 4 Meeting the Challenges: Solutions Afforded by MR; 5 Mandelate Racemase Structure: Ligand Binding Within a Catalytic Cage; 6 Evolutionary Relationships: A Mechanistic Link to Aldolases?; 7 Concluding Remarks; Acknowledgments Chapter Five: Striking Diversity in Holoenzyme Architecture and Extensive Conformational Variability in Biotin-Dependent CarboxylasesAbstract; 1 Introduction; 2 Structures of Conserved Components in Biotin-Dependent Carboxylases; 3 Extensive Diversity in Holoenzyme Architectures; 4 Extensive Conformational Variability; 5 Perspectives; Acknowledgments; Chapter Six: Enzymology of Microbial Dimethylsulfoniopropionate Catabolism; Abstract; 1 Introduction; 2 DMSP Demethylation Pathway and the Demethylase, DmdA; 3 DMSP Cleavage Enzymes 4 The CoA-Transferase Pathway of DMS and 3-Hydroxypropionate Formation Using DddD5 The Lyase Pathway of DMS and Acrylate Generation; 6 Summary and Perspective; Acknowledgments; Chapter Seven: Sortase Transpeptidases: Structural Biology and Catalytic Mechanism; Abstract; 1 Introduction; 2 Structural Biology: Enzyme Structure and Class-Specific Variations; 3 Structural Biology: Molecular Basis of Substrate Recognition; 4 Computational Studies; 5 Catalytic Mechanism; 6 In Vitro Transpeptidation Activity; 7 Conclusions and Future Directions
• Publisher Details: Cambridge, MA : Academic Press is an imprint of Elsevier
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 572/.7; Enzymology; Enzymes -- Structure; SCIENCE / Life Sciences / Biochemistry; Electronic books
• Languages: English
• ISBNs: 9780128118771; 0128118776
• Related ISBNs: 9780128118764
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (ScienceDirect, viewed July 13, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.