An introduction to systems biology : design principles of biological circuits /: design principles of biological circuits. (©2007)

• Record Type: Book
• Further Information: Note: Uri Alon.
• Other Names: Alon, Uri, 1969-
• Contents: INTRODUCTION ; TRANSCRIPTION NETWORKS, BASIC CONCEPTS ; Introduction; The Cognitive Problem of the Cell; Elements of Transcription Networks; Dynamics and Response Time of Simple Gene Circuits; AUTO-REGULATION, A NETWORK MOTIF ; Introduction; Patterns, Randomized Networks and Network Motifs; Autoregulation is a Network Motif; Negative Auto-Regulation Speeds the Response Time of Gene ; Circuits; Negative Auto-Regulation Promotes Robustness to Fluctuations; in Production; Positive auto-regulation speeds responses and widens cell-cell variability; Summary; THE FEEDFORWARD LOOP NETWORK MOTIF ; Introduction; The Number of Appearances of a Subgraph in Random; Networks; The Feedforward Loop (FFL) is a Network Motif; The Structure of the Feedforward Loop Circuit; Dynamics of the Coherent FFL with AND-Logic; The C1-FFL is a Sign-Sensitive Delay Element; The Incoherent FFL: a pulse generator and response accelerator; Why Are Some FFL Types Rare?; Convergent Evolution of FFLs; Summary; TEMPORAL PROGRAMS AND THE GLOBAL STRUCTURE OF TRANSCRIPTION NETWORKS ; Introduction; The Single-Input Module (SIM) Network Motif ; SIMs Can Generate Temporal Expression Programs; Topological Generalizations of Network Motifs; The Multi-Output FFL Can Generate FIFO Temporal Order; Signal Integration and Combinatorial Control: Bi-Fans and; Dense-Overlapping Regulons; Network Motifs and the Global Structure of Sensory; Transcription Networks; NETWORK MOTIFS IN DEVELOPMENTAL, SIGNAL-TRANSDUCTION AND NEURONAL NETWORKS ; Introduction; Network Motifs in Developmental Transcription Networks; Positive feedback loops and bistability; Motifs in Signal Transduction Networks; Information Processing Using Multi-Layer Perceptrons; Composite Network Motifs: Negative Feedback and Oscillator; Motifs; Network Motifs in the Neuronal Network of C. Elegans ; Summary; ROBUSTNESS OF PROTEIN CIRCUITS, THE EXAMPLE OF BACTERIAL CHEMOTAXIS ; The Robustness Principle; Bacterial Chemotaxis, or How Bacteria 'Think'; The Chemotaxis Protein Circuit of E. coli ; Two Models Can Explain Exact Adaptation, One is Robust and; the Other Fine Tuned; The Barkai-Leibler model; Individuality and Robustness in Bacterial Chemotaxis; ROBUST PATTERNING IN DEVELOPMENT ; Introduction to Morphogen Gradients; Exponential Gradients Are Not Robust; Increased Robustness by Self-Enhanced Morphogen; Degradation; Network Motifs That Provide Robust Patterning; The Robustness Principle Can Distinguish Between; Mechanisms of Fruit Fly Patterning; KINETIC PROOFREADING ; Introduction; Kinetic Proofreading of the Genetic Code Can Reduce Error; Rates of Molecular Recognition; Recognition of Self and Non-Self by the Immune System; Kinetic Proofreading May Occur in Diverse Recognition; Processes in the Cell; OPTIMAL GENE CIRCUIT DESIGN ; Introduction; Cost and Benefit Analysis of Gene circuits; Optimal Expression Level of a Protein Under Constant; Conditions; To Regulate or Not to Regulate: Optimal Regulation in Variable; Environments; Environmental Selection of the Feedforward Loop Network Motif; Summary; RULES FOR GENE REGULATION BASED ON ERROR MINIMIZATION ; Introduction; The Savageau Demand Rules; Rules for Gene Regulation Based on Minimal Error Load; Demand Rules for Genes with Multiple Regulators; Summary; EPILOGUE: Simplicity in Biology; APPENDIX A: The Input-Function of a Gene, Michaelis-Menten and Hill Equations; ; APPENDIX B: Multi-Dimensional Input-Functions; APPENDIX C: Graph Properties of Transcription Networks; APPENDIX D: Cell-Cell Variability in Gene Expression; GLOSSARY ; BIBLIOGRAPHY
• Publisher Details: Boca Raton, FL : Chapman & Hall/CRC
• Publication Date: 2007
• Copyright Date: 2007
• Extent: 1 online resource, illustrations (some color)
• Subjects: 570.285; Systems biology; Computational biology; Biological systems -- Mathematical models; Gene Regulatory Networks; Systems Biology -- methods; Biological systems -- Mathematical models; Computational biology; Systems biology
• Languages: English
• ISBNs: 9781420011432
• Related ISBNs: 142001143X; 1584886420; 9781584886426
• Notes: Note: Includes bibliographical references (pages 271-293) and index.; Note: Description based on print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.