Chemistry and molecular aspects of drug design and action. (©2008)

• Record Type: Book
• Further Information: Note: Editors, E.A. Rekka and P.N. Kourounakis.
• Other Names: Rekka, E. A; Kourounakis, P. N
• Contents: Inflammatory mechanisms in Alzheimer's disease and other neurodegenerative disorders / J. Rogers [and others] -- Treatment development strategies for Alzheimer's disease / E. Wülfert -- Lipoprotein-associated phospholipase A2 as a new prognostic factor for coronary artery disease / A. Tselepis -- Protein modifications by nitric oxide and reactive nitrogen species / H. Ischiropoulos -- Design, synthesis, and pharmacological evaluation of high affinity and selectivity sigma-1 and sigma-2 receptor ligands / J.H. Poupaert -- Synthesis of biologically active taxoids / K.C. Nicolaou and R.K. Guy -- From the molecular pharmacology to the medicinal chemistry of cannabinoids / D.M. Lambert -- New inhibitors of DNA topoisomerase in the treatment of experimental malignancies / C. Atassi -- Treatment of psoriasis with anthrones-biochemical aspects / W. Wiegrebe and K. Müller -- An appraisal of fomocaines, current situation, and outlook / H. Oelschläger and A. Seeling -- Ligands for the GABA recognition site at the GABAA receptor: structure-activity studies / B. Frølund [and others] -- Discovery of potent and selective inhibitors of human aldosterone synthase (CYP11B2): a new target for the treatment of congestive heart failure and myocardial fibrosis: a review / R.W. Hartmann [and others]. Thiocarboxanilides: a new class of non-nucleoside reverse transcriptase inhibitors (NNRTIS) with great potential for the treatment of human immunodeficiency virus type 1 (HIV-1) infections / E. De Clercq, A. Karlsson, and J. Balzarini -- Histamine H3-receptor agonists and antagonists: chemical, pharmacological, and clinical aspects / H. Stark and W. Schunack -- Anti-inflammatory actions of flavonoids and structural requirements / T. Theoharides -- Molecular mechanisms of H2O2-induced DNA damage: the action of desferrioxamine / M. Tenopoulou, P.-T Doulias, and D. Galaris -- LNA (locked nucleic acid) and functionalized LNA: towards efficient gene targeting / J. Wengel -- The effect of diet on drug metabolism / K.J. Netter -- Cytochromes P450 in the metabolism and bioactivation of chemicals / C. Ioannides -- In vitro methods to measure drug metabolism and metabolic interactions in drug discovery and development / O. Pelkonen [and others] -- How to probe the sites of action of drug molecules / A. Makriyannis and F. Bitter -- Lipophilicity as a descriptor of molecular properties in drug design / B. Testa [and others] -- Drug membrane interaction and the importance for drug transport, distribution, accumulation, efficacy, and resistance / J.K. Seydel [and others] -- Structure-based and computer-aided drug design / H. Kubinyi -- Physicochemical profiling in early drug discovery: new challenges at the age of high-throughput screen and combinatorial chemistry / B. Faller.
• Publisher Details: Boca Raton : Taylor & Francis
• Publication Date: 2008
• Copyright Date: 2008
• Extent: 1 online resource
• Subjects: 615/.19; Pharmaceutical chemistry; Drugs -- Design; Chemistry, Pharmaceutical; Drug Design; Pharmacologic Actions; Pharmaceutical industry; MEDICAL -- Drug Guides; MEDICAL -- Pharmacology; MEDICAL -- Pharmacy; MEDICAL -- Nursing -- Pharmacology; Drugs -- Design; Pharmaceutical chemistry; Electronic books
• Languages: English
• ISBNs: 9781420008272; 1420008277; 1281274437; 9781281274434
• Related ISBNs: 9780849390067; 0849390060
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.