High-throughput lead optimization in drug discovery. (©2008)

• Record Type: Book
• Further Information: Note: Edited by Tushar Kshirsagar.
• Other Names: Kshirsagar, Tushar
• Contents: Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarmni -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase : a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee.
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2008
• Copyright Date: 2008
• Extent: 1 online resource (ix, 243 pages), illustrations
• Subjects: 615/.19; High throughput screening (Drug development); Combinatorial chemistry; Drug development; Combinatorial Chemistry Techniques; Drug Design; Databases, Genetic; Gene Library; MEDICAL -- Drug Guides; MEDICAL -- Pharmacology; MEDICAL -- Pharmacy; MEDICAL -- Nursing -- Pharmacology; Combinatorial chemistry; Drug development; High throughput screening (Drug development); Arzneimittelforschung; High throughput screening; Kombinatorische Synthese; Electronic books
• Languages: English
• ISBNs: 9781420006964; 1420006967
• Related ISBNs: 9780849372681; 0849372682
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.