Handbook of adaptive designs in pharmaceutical and clinical development. (©2011)

• Record Type: Book
• Other Titles: Adaptive designs in pharmaceutical and clinical development
• Further Information: Note: Edited by Annpey Pong, Shein-Chung Chow.
• Other Names: Pong, Annpey; Chow, Shein-Chung, 1955-
• Contents: 1. Overview of adaptive design methods in clinical trials / Annpey Pong and Shein-Chung Chow -- 2. Fundamental theory of adaptive designs with unplanned design change in clinical trials with blinded data / Qing Liu and George Y.H. Chi -- 3. Bayesian approach for adaptive design / Guosheng Yin and Ying Yuan -- 4. The impact of protocol amendments in adaptive trial designs / Shein-Chung Chow and Annpey Pong -- 5. From group sequential to adaptive designs / Christopher Jennison and Bruce W. Turnbull -- 6. Determining sample size for classical designs / Simon Kirby and Christy Chuang-Stein -- 7. Sample size reestimation design with applications in clinical trials / Lu Cui and Xiaoru Wu -- 8. Adaptive interim analyses in clinical trials / Gernot Wassmer -- 9. Classical dose-finding trial / Naitee Ting -- 10. Improving dose-finding : a philosophic view / Carl-Fredrik Burman, Frank Miller, and Kiat Wee Wong -- 11. Adaptive dose-ranging studies / Marc Vandemeulebroecke [and others] -- 12. Seamless phase I/II designs / Vladimir Dragalin -- 13. Phase II/III seamless designs / Jeff Maca -- 14. Sample size estimation/allocation for two-stage seamless adaptive trial designs / Shein-Chung Chow and Annpey Pong -- 15. Optimal response-adaptive randomization for clinical trials / Lanju Zhang and William Rosenberger -- 16. Hypothesis-adaptive design / Gerhard Hommel -- 17. Treatment adaptive allocations in randomized clinical trials : an overview / Atanu Biswas and Rahul Bhattacharya -- 18. Integration of predictive biomarker diagnostics into clinical trials for new drug development / Richard Simon -- 19. Clinical strategy for study endpoint selection / Siu Keung Tse, Shein-Chung Chow, and Qingshu Lu -- 20. Adaptive infrastructure / Bill Byrom, Damian McEntegart, and Graham Nicholls. 21. Independent data monitoring committees / Steven Snapinn and Qi Jiang -- 22. Targeted clinical trials / Jen-Pei Liu -- 23. Functional genome-wide association studies of longitudinal traits / Jiangtao Luo [and others] -- 24. Adaptive trial simulation / Mark Chang -- 25. Efficiency of adaptive designs / Nigel Stallard and Tim Friede -- 26. Case studies in adaptive design / Ning Li, Yonghong Gao, and Shiowjen Lee -- 27. Good practices for adaptive clinical trials / Paul Gallo.
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2011
• Copyright Date: 2011
• Extent: 1 online resource (1 volume (various pagings)), illustrations
• Subjects: 615.5072/4; Clinical trials -- Handbooks, manuals, etc; Drugs -- Research -- Methodology -- Handbooks, manuals, etc; Clinical Trials as Topic -- methods; Research Design; Statistics as Topic -- methods; HEALTH & FITNESS -- Alternative Therapies; MEDICAL -- Healing; HEALTH & FITNESS -- Healing; BODY, MIND & SPIRIT -- Healing -- General; Clinical trials; Drugs -- Research -- Methodology; Electronic books; Handbooks and manuals
• Languages: English
• ISBNs: 9781439810170; 1439810176
• Related ISBNs: 9781439810163; 1439810168
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.