Kinetic modelling in systems biology. (©2009)

• Record Type: Book
• Further Information: Note: Oleg Demin, Igor Goryanin.
• Other Names: Demin, Oleg; Goryanin, Igor
• Contents: Introduction Systems Biology, Biological Knowledge, and Kinetic Modelling ; Dependence of enzyme reaction rate on the substrate concentration; What are the model limitations? Or, in other words, what can be modeled? Cellular Networks Reconstruction and Static Modelling ; Pathway reconstruction; The high-quality network reconstruction: description of the process; Visual notations: three categories Edinburgh Pathway Editor (EPE); Introduction; Feature summary of EPE; A flexible visual representation; Conclusion Construction and Verification of Kinetic Models ; Introduction; Basic principles of kinetic model construction; Basic principles of kinetic model verification; Study of dynamic and regulatory properties of the kinetic model Introduction to DBSolve ; Creation and analysis of the models using DBSolve: functional description Enzyme Kinetics Modelling ; Introduction; Basic principles of modeling individual enzymes and transporters; "Hyperbolic" enzymes; Allosteric enzymes; Transporters Kinetic Models of Biochemical Pathways ; Modelling of the mitochondrial Krebs cycle; Modelling of the Escherichia coli branched-chain amino acid biosynthesis Modelling of Mitochondrial Energy Metabolism ; Oxidative phosphorylation and superoxide production in mitochondria; Development of kinetic models; Description of individual processes of the model; Model predictions Application of the Kinetic Modelling Approach to Problems in Biotechnology and Biomedicine ; Study of the mechanisms of salicylate-hepatotoxic effect; Multiple target identification analysis for antituberculosis drug discovery; Application of the kinetic model of E. coli branched-chain amino acid biosynthesis to optimize production of isoleucine and valine Conclusion and Discussion References Index
• Publisher Details: Boca Raton, FL : CRC Press
• Publication Date: 2009
• Copyright Date: 2009
• Extent: 1 online resource (xxi, 332 pages), illustrations
• Subjects: 570.1/13 22; Biological systems -- Computer simulation; Biological systems -- Mathematical models; Systems Biology; Computer Simulation; Models, Theoretical; Biological systems -- Computer simulation; Biological systems -- Mathematical models; Biologi -- matematiska modeller; Electronic books
• Languages: English
• ISBNs: 1420011669; 9781420011661; 9781584886679; 1584886676; 1281863343; 9781281863348
• Related ISBNs: 1584886676
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.