Analytical methods in combinatorial chemistry. (©2011)

• Record Type: Book
• Further Information: Note: Bing Yan, Bin Zhang.
• Other Names: Yan, Bing; Zhang, Bin, 1968-
• Contents: Analytical issues in combinatorial chemistry; Combinatorial chemistry; Synthesis methods; Analytical challenges; Properties of solid supports ; Reaction Optimization Stage ; Library synthesis stage ; Lead selection and optimization stage ; ; An examination of the analytical sample: resin support ; Physical properties of resins; Resin type ; Resin bead size distribution ; Loading and the intraresin site distribution ; Thermal stability ; Chemical stability ; Resin swelling and solvation; Effects of swelling on resin ; Effects of swelling on reagent and solvent molecules ; Swelling ability of solvents ; Dynamic resin solvation ; Effects of the solvated resin on solid-phase reactions; The effects of support solvation on SPPS ; Resin support as another "solvent phase" ; Support effects on SPOS reaction kinetics ; Site separation and site interaction ; Solid support effects on product purity ; ; Solid-phase reaction optimization using FTIR; Comparison of FTIR and Raman techniques; Techniques ; Analysis of resin-bound compounds ; Comparison of techniques ; Monitoring of polymer-supported organic reactions ; The monitoring of reactions on polystyrene-based resin; Yes-and-no information ; Reaction kinetics on resin support ; Quantitative estimation of chemical conversions (%) on resin ; The selection of optimal reaction conditions using single-bead IR ; The monitoring of reactions on PS-PEG resins: comparing the reaction rate on PS and PS-PEG resins; Background ; Examples ; Examples: Peptide secondary structure on resin support ; The monitoring of reactions on surface-functionalized polymers; Techniques ; Examples ; Parallel reaction monitoring; ; Reaction optimization using MS and NMR methods; MS methods; NMR methods; Gel-phase NMR ; Magic angle spinning (MAS) NMR ; Other NMR methods ; ; Reaction optimization using spectrophotometric and other methods; Qualitative analysis of amines; Quantitative analysis of amines; Quantitative spectroscopic methods for organic functional groups; Quantitation of aldehyde/ketone groups ; Quantitation of hydroxyl groups on resin ; Quantitation of carboxyl groups on resin ; Quantitation of polymer-supported sulfhydryl groups ; Combustion elemental analysis methods; Analysis of resin-bound organic compounds ; Quantitatively monitoring SPOS reactions ; Electrochemical methods; On-resin X-ray, EPR, SERS, and fluorescence methods; ; Quality control of combinatorial libraries; Analysis of discrete compound libraries; MS analysis ; MS-guided purification ; High-throughput NMR ; Analysis of pooled libraries; Theoretical calculation of mass distribution ; MS analysis ; High-resolution MS ; Tandem MS ; Liquid chromatography (LC)/MS and capillary electrophoresis (CE)/MS ; NMR methods for mixture analysis ; HPLC for analyzing compounds from discrete and mixture libraries; HPLC with a chemiluminescence nitrogen detector (CLND) ; Evaporative light scattering detector (ELSD) ; ; High-throughput purification; Nonchromatographic high-throughput purification methods; Chromatographic high-throughput purification methods; Supercritical fluid chromatographic purification methods; Purification methods based on fluorous chemistry separation technique; Fluorous liquid–liquid extraction (F-LLE) ; Fluorous solid-phase extraction (F-SPE) ; Fluorous HPLC (F-HPLC) ; Fluorous-flash chromatography (F-FC) ; ; Final Thoughts and Future Perspectives; Stability of compound collections; Nano-combinatorial library and associated analytical issues; Green process and technologies;
• Edition: 2nd ed
• Publisher Details: Boca Raton, FL : CRC Press
• Publication Date: 2011
• Copyright Date: 2011
• Extent: 1 online resource (xiii, 224 pages), illustrations
• Subjects: 615/.19; Combinatorial chemistry; MEDICAL -- Drug Guides; MEDICAL -- Pharmacology; MEDICAL -- Pharmacy; MEDICAL -- Nursing -- Pharmacology; Combinatorial chemistry; Electronic books; Electronic books
• Languages: English
• ISBNs: 9781420003529; 1420003526
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.