Radiation injury prevention and mitigation in humans. (2012)

• Record Type: Book
• Further Information: Note: Kedar N. Prasad.
• Other Names: Prasad, Kedar N
• Contents: Growing Health Concerns with Respect to Low Doses of Ionizing Radiation: Can We Prevent and/or Mitigate Them?; Introduction; Prevention of Radiation Injuries; Mitigation of Radiation Injuries; The Concept of a Bioshield against Radiation Damage; Summary Physics of Radiological Weapons and Nuclear Reactors; Introduction; Structure of an Atom; Isotopes; Radioactivity; Interactions of Radiation with Matter; Nuclear Fission; Nuclear Fusion; Physics of Nuclear Reactors; Nuclear Accidents; Summary; References Acute Radiation Damage by High Doses of Ionizing Radiation in Humans; Introduction; Radiation-Induced Free Radicals; Concept of Radiosensitivity of Cells; Cellular Radiobiology; Biochemical Changes; Radiation Syndromes; Acute Radiation Sickness (ARS) in Accidently Exposed Individuals; Damage to Organ Systems; Genetic Basis of Radiation Response in Vitro and in Vivo; Mutations and Chromosomal Damage; Cellular Immune Response to Ionizing Radiation; Radiation Effects on Fetus; Radiation Effects on Embryos during Preimplantation of Zygotes; Radiation Effects on Embryos after Implantation of Zygotes; Radiation Effects on Embryos during Organogenesis; Radiation Effects on the Eye of Embryos; Radiation Effects on the Gonads of Embryos; Identification of a Novel Mechanism of Action of Radiation; Summary; References Long-Term Damages among Survivors of High Doses of Ionizing Radiation; Introduction; Spontaneous Cancer Incidence, Mortality, and Cost; Study of Carcinogenesis in Experimental Models (Tissue Culture and Animals; Proposed Stages of Carcinogenesis; Effect of Interaction between Radiation and Chemicals on Carcinogenesis; Radiation-Induced Cancer Incidence in Humans; Incidence of Radiation-Induced Cancer in Humans; Late Effects of High-Doses of Radiation on the Risk of Non-Neoplastic Diseases; Summary; References Prevention and Mitigation of Acute Radiation Sickness (ARS); Introduction; Definition of Radioprotective and Radiation Mitigating Agents; Concept of a Bioshield against Radiation Damage; Prevention of ARS by Radioprotective Agents; Factors to be Considered in the Study of Radioprotective Agents; Radioprotective Pharmacological Agents; Radioprotective Pharmacological Agents Not Approved by the FDA; Radioprotective Drugs Approved by the FDA for Other Indications in Humans; Radioprotective Herbal Extracts Not Requiring FDA Approval; Limitations of Using Most Identified Radioprotective Agents for Prevention of ARS in Humans; Radioprotective Dietary and Endogenous Antioxidants Not Requiring FDA Approval; Scientific Rationale for Using Multiple Antioxidants; Scientific Rationale for Utilizing Oral Route of Administration; Scientific Rationale for Administering Multiple Antioxidants before and after Irradiation; Animal Studies to Demonstrate the Radioprotective Efficacy of a Mixture of Multiple Dietary and Endogenous Antioxidants Administered Orally before and/or after Irradiation; Proposed Recommendation for Using BioShield-R2 in Combination with Standard Therapy for Prevention of ARS in Humans; Mitigation of ARS; Drugs and Biologics Approved by the FDA; Drugs and Biologics Not Approved by the FDA; Radioprotective Dietary and Endogenous Antioxidants Not Requiring Approval by the FDA; Potential Candidates for an Ideal Bioshield against ARS; Proposed Recommendations for Using a Micronutrient Preparation (BioShield-R3) in Combination with Standard Therapy for Mitigating ARS in Humans; Summary; References Prevention and Mitigation of Late Adverse Effects of High Radiation Doses; Introduction; Studies on the Role of Antioxidants in Cancer Prevention; Properties of Antioxidants Relevant to Cancer Prevention; Cancer Prevention Studies with Antioxidants; Cancer Risk after Treatment with Multiple Dietary Antioxidants; Cancer Risk after Treatment with Vitamin D and Calcium; Cancer Risk after Treatment with Folate and B Vitamins; Cancer Risk after Treatment with Fat and Fiber; Essential Factors for an Effective Cancer Prevention Strategy; Proposed Cancer Prevention Strategy for Radiation-Exposed Populations; Safety of Micronutrients in BioShield-R2; BioShield-R2 and the Risk of Nonneoplastic Diseases; Summary; References Health Risks of Low Doses of Ionizing Radiation; Introduction; Sources of Background Radiation; Diagnostic Radiation Procedures; Radiation Workers; Consequences of Exposure to Low Doses of Radiation; Models Used for Risk Estimates of Radiation-Induced Cancer; Cancer Risks in Populations Exposed to Diagnostic Radiation Procedures; Cancer Risk among Radiation Workers; Cancer Risk in Military and Civilian Pilots and Flight Attendants; Cancer Risk among Frequent Flyers; Risk of Low-Dose Radiation-Induced Nonneoplastic Diseases; Summary; References Prevention and Mitigation against Radiological Weapons and Nuclear Plant Accidents; Introduction; Current Preventive Recommendations to Reduce Radiation Doses after Explosion of a Dirty Bomb or a Nuclear Power Plant Accident; Proposed Preventive Biological Radiation Protection Strategy after Explosion of a Dirty Bomb or a Nuclear Power Plant Accident; Current and Proposed Preventive Recommendations to Reduce Radiation Doses after Explosion of an Atom Bomb; Current and Proposed Mitigation Strategy to Reduce Damage after Irradiation with Low or High Doses of Radiation; Use of BioShield-R2 and Bioshield-R3; Summary; References Prevention and Mitigation of Damage after Low Radiation Doses; Introduction; Application of the Concept of a Bioshield for Prevention of Radiation Damage; BioShield-R1 for Individuals Receiving Diagnostic Radiation Procedures and Frequent Flyers; BioShield-R2 for Radiation Workers and Crews of Commercial and Military Aircraft; Summary; References Implementation Plans for Prevention and Mitigation of Radiation Injury; Introduction; Radiation Protection Strategies; Implementation Plans for Radiation Protection Strategies; Educational Programs on the Effects of Ionizing Radiation Exercises and Drills; Stockpiling of Radiation Preventive and Mitigating Agents for Biological Protection; Responsible Agencies for Stockpiling Radiation Preventive and Mitigating Agents; Summary Health Risks of Nonionizing Radiation and Their Prevention and Mitigation ; Introduction; Ultraviolet Radiation; Biological Effects of UV Radiation; Mechanisms of UV Radiation–Induced Damage; Protection against UV Radiation–Induced Damage to the Skin; Other Forms of Electromagnetic Radiation; Cell Phones; Mechanisms of Cell Phone–Induced Damage and Its Protection by Antioxidants; Infrared Radiation (IR); Biological Effects of Infrared Radiation; Effect of Magnetic Field; Summary; References Index
• Publisher Details: Place of publication not identified : CRC Press
• Publication Date: 2012
• Extent: 1 online resource, illustrations
• Subjects: 363.32557; Radiation -- Safety measures; Radiation injuries -- Prevention; Emergency management
• Languages: English
• ISBNs: 9781466559196; 1466559195
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.