Randomized phase II cancer clinical trials. (2013)

• Record Type: Book
• Further Information: Note: Sin-Ho Jung.
• Other Names: Jung, Sin-Ho
• Contents: Introduction Single-Arm Phase II Trial Designs; Single-Stage Designs; Two-Stage Designs; Two-Stage Designs with Both Upper and Lower Stopping Values Inference on the Binomial Probability in Single-Arm Multistage Clinical Trials; Point Estimation; Confidence Intervals; P-Values; When Realized Sample Size Is Different from That Specified in Design Single-Arm Phase II Clinical Trials with Time-to-Event Endpoints; A Test Based on Median Survival Time; Maximum Likelihood Method for Exponential Distribution; One-Sample Log-Rank Test; Two-Stage Trials Using One-Sample Log-Rank Test; Binomial Testing on t -Year Survival Probability Single-Arm Phase II Trials with Heterogeneous Patient Populations: Binary and Survival Outcomes; Binary Outcome Case; Survival Outcome Case: Stratified One-Sample Log-Rank Test Randomized Phase II Trials for Selection: No Prospective Control Arms; With a Historical Control; When No Historical Control Exists; Extension to More Than Two Arms Randomized Phase II Cancer Clinical Trials with a Prospective Control on Binary Endpoints (I): Two-Sample Binomial Test; Two-Sample Binomial Test; Two-Stage Designs with Both Upper and Lower Stopping Values; Discussions Randomized Phase II Cancer Clinical Trials with a Prospective Control on Binary Endpoints (II): Fisher’s Exact Test; Single-Stage Design; Two-Stage Design; Extensions; Discussions Randomized Phase II Trials with Heterogeneous Patient Populations: Stratified Fisher’s Exact Test; Single-Stage Stratified Fisher’s Exact Test; Two-Stage Designs with an Interim Futility Test Randomized Phase II Clinical Trials Based on Survival Endpoints: Two-Sample Log-Rank Test; Two-Sample Log-Rank Test; Two-Stage Log-Rank Test; Stratified Two-Sample Log-Rank Test for Single-Stage Designs Some Flexible Phase II Clinical Trial Designs; Comparing Survival Distributions under General Hypothesis Testing; Randomized Phase II Trials for Comparing Maintenance Therapies Index References appear at the end of each chapter.
• Publisher Details: Hoboken : CRC Press
• Publication Date: 2013
• Extent: 1 online resource (236 pages)
• Subjects: 616.99406; Clinical trials -- Statistical methods; Cancer -- Research -- Statistical methods; Clinical Trials, Phase II as Topic; Randomized Controlled Trials as Topic; Neoplasms -- therapy; Neoplasms -- drug therapy; HEALTH & FITNESS -- Diseases -- Cancer; MEDICAL -- Oncology; Cancer -- Research -- Statistical methods; Clinical trials -- Statistical methods; Electronic books; Electronic books
• Languages: English
• ISBNs: 9781439871867; 1439871868
• Related ISBNs: 9781439871850
• Notes: Note: Includes bibliographical references.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.