Crumbling genome : the impact of deleterious mutations on humans /: the impact of deleterious mutations on humans. (2017)

• Record Type: Book
• Further Information: Note: Alexey S. Kondrashov.
• Authors: Kondrashov, Alexey S, 1957-
• Contents: 1 Genotypes and Phenotypes 1 ; ; 1.1 DNA is a Text 1; ; 1.2 Genomes Small and Large 6; ; 1.3 Genes and Intergenic Regions 7; ; 1.4 Cells, Mitosis, and Meiosis 14; ; 1.5 From Genotype to Phenotype 17; ; Further Reading 21; ; 2 Mendelian Inheritance and Population Genetics 23 ; ; 2.1 Inheritance is Discrete 23; ; 2.2 Populations are Genetically Variable 27; ; 2.3 Loci and Genes 33; ; 2.4 Effects of Alleles on Phenotypes 37; ; 2.5 Mendelian Traits and Diseases 43; ; Further Reading 46; ; 3 Complex Traits and Their Inheritance 49 ; ; 3.1 Complex Inheritance of Phenotypes 49; ; 3.2 Properties of a Complex Trait 52; ; 3.3 Complex Traits in Populations 55; ; 3.4 Effects of Heredity and Environment on Complex Traits 60; ; 3.5 Polymorphic Loci Behind Complex Variation 64; ; Further Reading 68; ; 4 Unavoidable Mutation 71 ; ; 4.1 Phenomenon of Mutation 71; ; 4.2 Kinds of Mutations 73; ; 4.3 Spontaneous Mutation 75; ; 4.4 Evolution of Mutation Rates 77<br />; 4.5 Artificial Mutagenesis and Antimutagenesis 79; ; Further Reading 81; ; 5 Struggle for Fidelity 83 ; ; 5.1 Fidelity of DNA Replication 83; ; 5.2 Cleaning Up After the Replisome 88; ; 5.3 Dealing with DNA Damages 91; ; 5.4 Harms of Broken Maintenance 96; ; 5.5 Mechanisms of Mutation 100; ; Further Reading 104; ; 6 Mutation Rates 107 ; ; 6.1 Measuring Mutation Rates 107; ; 6.2 Data on Mutation Rates 109; ; 6.3 Guilty Older Men 112; ; 6.4 Rates of Phenotypically Drastic Mutations 114; ; 6.5 Mild Mutations and Mutational Pressures 118; ; Further Reading 121; ; 7 Natural Selection 123 ; ; 7.1 Vulnerable Adaptations and Their Evolutionary Origin 123; ; 7.2 Two Basic Characteristics of Selection 127; ; 7.3 Measuring Natural Selection 129; ; 7.4 Selection at a Polymorphic Locus 132; ; 7.5 Selection on a Quantitative Trait 135; ; Further Reading 138; ; 8 Functioning DNA and Junk DNA 141 ; ; 8.1 Selective Neutrality and Random Drift 141; ; 8.2 Effective Population Size 144; ; 8.3 Junk DNA Provides the Simplest Evidence for Evolution 144; ; 8.4 Finding Functioning Genome Segments 145; ; 8.5 The Genomic Rate of Deleterious Mutations 147; ; Further Reading 148; ; 9 It Takes All the Running You Can Do 149 ; ; 9.1 Middle Class Neighborhood for Drosophila 149; ; 9.2 Selection Against Deleterious Alleles 153; ; 9.3 Mutation–Selection Equilibrium 155; ; 9.4 Inbreeding Depression 158; ; 9.5 Dangerous Slightly Deleterious Alleles 160; ; Further Reading 162; ; 10 Phenomenon of Imperfection 165 ; ; 10.1 Phenotypic and Genotypic Imperfection 165; ; 10.2 Five Evolutionary Causes of Imperfection 168; ; 10.3 Weakly Perfect Human Genotypes and Phenotypes 171; ; 10.4 Native, Novel, and Optimal Environments 173; ; 10.5 Factors, Exacerbating Mutation Imperfection 175; ; Further Reading 176; ; 11 Our Imperfect Fitness 177 ; ; 11.1 Properties of an Allele 177; ; 11.2 Human Derived Alleles 180; ; 11.3 Average Imperfection of a Genotype 186; ; 11.4 Variation Among Genotypes 190; ; 11.5 Selection in Modern Human Populations 192; ; Further Reading 197; ; 12 Our Imperfect Wellness 199 ; ; 12.1 Qualitative Characteristics of Wellness 199; ; 12.2 Quantitative Traits 206; ; 12.3 Contributions of Heredity and Environment 208; ; 12.4 Wellness?]impairing Alleles 211; ; 12.5 Genetic Architecture of Wellness 215; ; Further Reading 217; ; 13 Mutational Pressure on Our Species 219 ; ; 13.1 Mutational Pressure on Diseases 219; ; 13.2 Mutational Pressure on Quantitative Traits 225; ; 13.3 Possible Increase of the Mutational Pressure 226; ; 13.4 De Novo Mutations and Human Wellness 228; ; 13.5 Optimistic and Pessimistic Scenarios 230; ; Further Reading 231; ; 14 Ethical Issues 233 ; ; 14.1 Lessons from History 233; ; 14.2 Modern Practices 237; ; 14.3 Humanist Ethics and the Main Concern 241; ; 14.4 The Main Concern and Ethical Dilemmas 244; ; 14.5 Role of Scientists 247; ; Further Reading 250; ; 15 What to Do? 253 ; ; 15.1 Conditionally Beneficial or Unconditionally Deleterious? 253; ; 15.2 Mutationless Utopia: What Could It Be? 257; ; 15.3 Mutationless Utopia: Is It Ever Going to Happen? 261; ; 15.4 What Can I Do Without Germline Genotype Modification? 265; ; 15.5 Prognosis 268; ; Further Reading 269; ; Index
• Edition: 1st
• Publisher Details: Chichester, West Sussex : Wiley Blackwell
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 572.838; Evolutionary genetics; Mutation (Biology)
• Languages: English
• ISBNs: 9781118952139; 9781118952122
• Related ISBNs: 9781118952115
• Notes: Note: Description based on CIP data; item not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.