Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) : the quintessential moonlighting protein in normal cell function and in human disease /: the quintessential moonlighting protein in normal cell function and in human disease. (2017)

• Record Type: Book
• Further Information: Note: Michael A. Sirover, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
• Authors: Sirover, Michael A
• Contents: Section I. The Role of Moonlighting GAPDH in Normal Cell Function. The role of moonlighting GAPDH in cell proliferation : the dynamic nature of GAPDH expression and subcellular localization -- Moonlighting GAPDH and the transcriptional regulation of gene expression : multiprotein complex formation and mechanisms of nuclear translocation -- The diversity of moonlighting GAPDH function in posttranscriptional RNA regulation : mRNA stability, tRNA processing, and viral pathogenesis -- The role of moonlighting GAPDH in membrane structure and function : membrane fusion and iron metabolism -- The role of moonlighting GAPDH in intracellular membrane trafficking : tubulin regulation and modulation of cytoskeletal structure -- Moonlighting GAPDH and the maintenance of DNA integrity : preservation of genetic information and cancer facilitation -- Moonlighting GAPDH in neuronal structure and function : regulation of ion channels and signal transduction -- Section II. Physiological Stress and GAPDH Functional Diversity. The significance of nitric oxide-modified GAPDH : regulation of apoptosis, cell signaling, and heme metabolism -- GAPDH and hypoxia : mechanisms of cell survival during oxygen deprivation -- Moonlighting GAPDH and ischemia : cellular and molecular effects of oxygen deprivation and reperfusion -- Section II. The Pathology of GAPDH Functional Diversity. GAPDH and tumorigenesis : molecular mechanisms of cancer development and survival -- Moonlighting GAPDH and age-related neurodegenerative disease : diversity of protein interactions and complexity of function -- Functional diversity of GAPDH in infection and immunity : the complexity of "simple" organisms -- Moonlighting GAPDH and diabetes : pleiotropic effects of perturbations in GAPDH structure and function -- Section IV. The Pharmacology of Moonlighting GAPDH -- Section V. The Unique Role of Sperm-Specific GAPDH -- Section VI. Discussion.
• Publisher Details: Place of publication not identified : Academic Press
• Publication Date: 2017
• Extent: 1 online resource (324 pages)
• Subjects: 572.791; Aldehyde dehydrogenase; Glycolysis; Aldehyde Dehydrogenase; Aldehyde dehydrogenase
• Languages: English
• ISBNs: 9780128098981; 0128098988
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.