Epigenetics and systems biology. (2017)

• Record Type: Book
• Further Information: Note: Leonie Ringrose.
• Authors: Ringrose, Leonie
• Contents: Section 1: Introduction Section 2: Where am I? Genomic features and DNA sequence principles defining sites of epigenetic regulation: Machine learning Introduction to section 2 Chapter 1: Computational identification of Polycomb/Trithorax Response Elements Marc Rehmsmeier Chapter 2: Modeling Chromatin States Marc Corrales and Guillaume Filion Chapter 3: Crossing borders: modeling approaches to understand chromatin domains and their boundaries Benjamin L. Moore, Colin A. Semple Chapter 4: Inferring chromatin signaling from genome-wide ChIP-seq data Juliane Perner & Ho-Ryun Chung Section 3. Everything’s Moving: In vivo dynamics of epigenetic regulators : Kinetic models based on ordinary differential equations (ODEs) Introduction to section 3 Chapter 5: “In vivo biochemistry”: Absolute quantification and kinetic modeling applied to Polycomb and Trithorax regulation Leonie Ringrose Chapter 6: Modeling distributive histone modification by Dot1 methyltransferases: from mechanism to biological insights Dirk De Vos, Hanneke Vlaming, Barbara M. Bakker, Fred van Leeuwen Section 4: Reconciling randomness and precision: Bistable epigenetic memory and switching: Stochastic models Introduction to section 4 Chapter 7: Modeling bistable chromatin states Ian B. Dodd and Kim Sneppen Chapter 8: Quantitative environmentally-triggered switching between stable epigenetic states Rea Antoniou-Kourounioti & Martin Howard Section 5. The third and fourth dimensions: Chromosomal long range interactions : Polymer models Introduction to section 5 Chapter 9: On the nature of chromatin 3D organization: lessons from modelling Mario Nicodemi and Ana Pombo Chapter 10: From chromosome conformation capture to polymer physics and back: Investigating the three-dimensional structure of chromatin within topological associating domains Guido Tiana, Edith Heard, Luca Giorgetti Chapter 11: A combination approach based on live-cell imaging and computational modeling to further our understanding of chromatin, epigenetics, and the genome Kayo Hibino, Kazunari Kaizu, Koichi Takahashi and Kazuhiro Maeshima Chapter 12: Capturing chromosome structural properties from their spatial and temporal fluctuations Aurélien Bancaud, Olivier Gadal, Kerstin Bystricky
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 572.865; Epigenetics; Systems biology
• Languages: English
• ISBNs: 9780128030769
• Related ISBNs: 9780128030752
• Notes: Note: Description based on CIP data; item not viewed.
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