Protein kinases in development and disease. (2017)

• Record Type: Book
• Further Information: Note: Edited by Andreas Jenny.
• Editors: Jenny, Andreas
• Contents: Front Cover; Protein Kinases in Development and Disease; Copyright; Contents; Contributors; Preface; References; Chapter One: WNK Kinases in Development and Disease; 1. Introduction; 2. The WNK-SPAK/OSR1 Kinase Cascade: Roles in Physiology and Disease; 2.1. Overview of the WNK-SPAK/OSR1 Kinase Cascade; 2.2. WNK-SPAK/OSR1 Signaling in Invertebrates; 2.2.1. WNK-SPAK/OSR1 Signaling Regulates NKCC in Drosophila Renal Tubule Function; 2.2.2. WNK-SPAK/OSR1 Signaling in C. elegans and Chloride Channel Regulation; 2.3. WNK-SPAK/OSR1 Signaling in Osmoregulation 2.4. The Role of Mouse Protein-25 in WNK-SPAK/OSR1 Signaling3. Emerging Functions of the WNK Signaling Axis in Development; 3.1. Mammalian WNKs; 3.2. Zebrafish Wnk1a/b Have Roles in Angiogenesis and Neural Development; 3.3. Insights from the Drosophila Wnk-Frayed Axis; 3.3.1. A Conserved Role of Wnk in the Activation of Arrowhead/Lhx8; 3.3.2. Wnk in Wnt Signaling; 3.3.3. Intriguing Issues to Be Addressed; 4. Functions of WNKs in Cancer; 5. Conclusions; Acknowledgments; References; Chapter Two: SGK1: The Dark Side of PI3K Signaling; 1. Introduction: The Glucocorticoid-Regulated Kinase Family 2. SGK1: Expression and Stability Control3. SGK1 Is Activated in a PI3K-Dependent Manner; 4. AKT and SGK1: Target Overlap and Selectivity; 5. Roadblocks to Defining Specific SGK1 Functions; 6. SGK1 in Development and Differentiation; 6.1. Ion Transport; 6.2. Implantation and Pregnancy; 6.3. Myocardial Injury; 6.4. Muscle Mass; 6.5. T Cell Activation; 6.6. Macrophage Motility and Function; 6.7. Insulin Sensitivity; 7. SGK1 and Cancer; 8. Concluding Remarks; Acknowledgments; References; Chapter Three: Homeodomain-Interacting Protein Kinases: Diverse and Complex Roles in Development and Disease 1. Introduction1.1. Hipk Protein Family; 1.2. Dynamic Tissue-Specific and Intracellular Localization of Hipk Proteins; 2. Requirements for Hipk Proteins During Development; 2.1. Regulation of Cell Proliferation and Cell Death; 2.2. Neuronal Development and Survival; 2.3. Angiogenesis and Hematopoiesis; 3. Hipk Roles in Regulation of Diverse Signaling Pathways; 3.1. Hipk Antagonizes the Global Corepressor Gro; 3.2. Modulating the Cellular Response to DNA Damage Through p53; 3.3. Regulation of Wnt Signaling by Hipks; 3.4. Hipk Promotes Yki Activity in the Hippo Pathway 3.5. JNK Signaling Is Modulated Through Hipk3.6. Hipk Is Required for JAK/STAT Activity in Normal Development and Tumorigenesis; 4. Regulation of Hipk Activity; 4.1. Phosphorylation; 4.2. SUMO Modification; 4.3. Ubiquitin and Proteasomal Degradation; 4.4. Acetylation; 4.5. Regulation of Hipk Gene Expression; 4.6. Drug-Based Inhibition of Hipk; 5. Hipks in Disease; 5.1. Hipks as Tumor Suppressors in Cancer; 5.2. Hipks as Oncogenic Factors in Cancer; 5.3. Hipks and Fibrosis; 6. Conclusions; Acknowledgments; References; Chapter Four: ROR-Family Receptor Tyrosine Kinases
• Publisher Details: Cambridge, MA : Academic Press is an imprint of Elsevier
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 572/.792; Protein kinases; SCIENCE / Life Sciences / Biochemistry; Electronic books
• Languages: English
• ISBNs: 9780128016244; 0128016248
• Related ISBNs: 9780128015131
• Notes: Note: Online resource; title from PDF title page (ScienceDirect, viewed March 3, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.