Introduction to Cancer Metastasis. (2016)

• Record Type: Book
• Further Information: Note: Aamir Ahmad.
• Editors: Ahmad, Aamir
• Contents: Front Cover; INTRODUCTION TO CANCER METASTASIS; Series Page; INTRODUCTION TO CANCER METASTASIS; Copyright; Contents; List of Contributors; Preface; I -- CANCER METASTASIS FROM PRIMARY ORGANS; 1 -- Cancer Metastasis: An Introduction; 1. INTRODUCTION; 2. DISRUPTION OF CELL ADHESION: INITIATION OF METASTASIS; 2.1 Adherens Junctions; 2.2 Tight Junctions; 3. MATRIX METALLOPROTEINASES IN CANCER METASTASIS; 4. EMT IN CANCER METASTASIS; 5. ORGAN-SPECIFIC METASTASIS; 6. MICRORNAS AND CANCER STEM CELLS IN CANCER METASTASIS; 7. CONCLUSIONS AND PERSPECTIVES; References; 2 -- Breast Cancer Metastasis. 1. INTRODUCTION2. BIOLOGY; 2.1 Breast Cancer Proliferation Signals; 2.2 Breast Cancer Microenvironment; 2.3 Disseminated Tumor Cells and Circulating Tumor Cells; 2.4 Breast Cancer Dormancy; 2.5 Cancer Stem Cells; 2.6 Intrinsic Subtypes; 3. METASTATIC DISSEMINATION; 3.1 Clinical Symptoms; 3.2 Locoregional Recurrence; 3.3 Bone Metastasis; 3.4 Lung Metastasis, Pleural Metastasis; 3.5 Liver Metastasis; 3.6 Brain Metastasis; 3.7 Peritoneal Dissemination; 4. PROGNOSTIC FACTORS AFTER RECURRENCE; 5. TREATMENT FOR METASTATIC BREAST CANCER; 5.1 Endocrine Therapy. 5.1.1 Selective Estrogen Receptor Modulators5.1.2 Aromatase Inhibitors; 5.1.3 Selective Estrogen Receptor Downregulators; 5.2 Chemotherapy; 5.2.1 Anthracyclines; 5.2.2 Taxanes; 5.2.3 Vinorelbine; 5.2.4 Capecitabine; 5.2.5 Eribulin; 5.2.6 Platinum Salts; 5.3 Metronomic Chemotherapy; 5.4 Molecular Targeted Therapy; 5.4.1 Trastuzumab; 5.4.2 Lapatinib; 5.4.3 T-DM1; 5.4.4 Pertuzumab; 5.4.5 Bevacizumab; 5.4.6 Everolimus; 5.5 Bisphosphonate; 5.6 RANK-Ligand (RANKL); 5.7 Radiotherapy; 5.8 Surgery; 5.9 Palliative Care; 6. CONCLUSIONS; References; 3 -- Prostate Cancer Metastasis. 1. EPIDEMIOLOGY AND OVERVIEW OF METASTATIC PROSTATE CANCER2. CELLULAR BIOLOGY OF PROSTATE CANCER METASTASES; 2.1 The Androgen Receptor Signaling Pathway; 2.2 The Phosphatidyl Inositol 3-Kinase/Akt-Signaling Pathway; 2.3 Cell Cycle Pathways; 2.4 DNA Repair Pathways; 2.5 Wnt Pathways; 2.6 Coregulator Factors; 3. THE METASTATIC CASCADE; 3.1 Bone Metastases; 3.2 Lymph Node Metastases; 3.3 Visceral Metastases; 3.4 Clinical Considerations in Prostate Cancer Metastasis; 3.4.1 Disease Recurrence and Risk Assessment; 3.5 Overview of Treatment for Prostate Cancer Metastases. 3.6 Treatment of Symptomatic Metastatic Disease3.7 Future Areas of Development; 3.8 Liquid Biopsy and Precision Medicine; 3.9 Imaging Modalities; 3.10 Investigational Therapies; 4. CONCLUSIONS; References; 4 -- Lung Cancer Metastasis; 1. GENERAL INFORMATION; 2. MECHANISM OF METASTASIS; 3. MOLECULAR MECHANISM IN THE REGULATION OF LUNG CANCER METASTASIS; 4. EPITHELIAL TO MESENCHYMAL TRANSITION IN LUNG CANCER; 5. CANCER STEM CELLS; 6. CONCLUDING REMARKS; Acknowledgments; References; 5 -- Cervical Cancer Metastasis; 1. INTRODUCTION; 2. RISK FACTORS; 3. PATHOGENESIS; 4. HISTOPATHOLOGY.
• Publisher Details: Place of publication not identified : Academic Press
• Publication Date: 2016
• Extent: 1 online resource (416 pages)
• Subjects: 616.994; Metastasis; Medicine; Oncology; MEDICAL / Oncology; Electronic books
• Languages: English
• ISBNs: 9780128040331; 0128040335
• Related ISBNs: 0128040033; 9780128040034
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.