Antisense-based drugs and therapeutics : preclinical and clinical considerations for development /: preclinical and clinical considerations for development. (2016)

• Record Type: Book
• Further Information: Note: Nicolay Ferrari, Rosanne Seguin.
• Authors: Ferrari, Nicolay; Seguin, Rosanne
• Contents: List of Contributors Preface Table of Contents Chapter 1 Mechanisms of Oligonucleotide Actions Chapter 2 The Medicinal Chemistry of Antisense Oligonucleotides Chapter 3 Cellular Pharmacology of Antisense Oligonucleotides Chapter 4 Pharmacokinetics and Pharmacodynamics of Antisense Oligonucleotides Chapter 5 Tissue Distribution, Metabolism and Clearance Chapter 6 Hybridization-independent Effects - Principles and Specific Considerations for Oligonucleotide Drugs Chapter 7 Hybridization-Dependent Effects – The Prediction, Evaluation and Consequences of Unintended Target Hybridization Chapter 8 Class-related proinflammatory effects Chapter 9 Exaggerated Pharmacology Chapter 10 Genotoxicity Tests for Novel Oligonucleotide-Based Therapeutics Chapter 11 Reproductive and Developmental Toxicity Testing Strategies for Oligonucleotide-based Therapeutics Chapter 12 Specific Considerations for Preclinical Development of Inhaled Oligonucleotides Chapter 13 Lessons Learned in Oncology Programs Chapter 14 Inhaled Antisense for Treatment of Respiratory Disease Chapter 15 Antisense oligonucleotides for treatment of neurology diseases Chapter 16 Nucleic Acids as Adjuvants Chapter 17 Splice-switching Oligonucleotides Chapter 18 CMC Aspects for the Clinical Development of Spiegelmers
• Edition: 1st
• Publisher Details: Hoboken, New Jersey : John Wiley & Sons, Inc
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 615.19; Drug development; Antisense nucleic acids -- Therapeutic use; Oligonucleotides -- Therapeutic use
• Languages: English
• ISBNs: 9781119070306
• Related ISBNs: 9781119070290
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.