Evidence-based evolutionary medicine. (2016)

• Record Type: Book
• Further Information: Note: John S. Torday.
• Authors: Torday, John S; Blackstone, Neil W; Rehan, Virender K
• Contents: Foreword Chapter 1: A Brief History of Evolutionary Thinking; 1.1 Summary; 1.2 Introduction; 1.3 Darwin; 1.4 Darwin’s Theory; 1.5 The Modern Synthesis; 1.6 The Darkest Chapter; 1.7 Conclusions; 1.8 References Chapter 2: Outlining the Major Transitions in the History of Life; 2.1 Summary; 2.2 Introduction; 2.3 The Major Transitions; 2.4 Conclusions; 2.5 References Chapter 3: One central mystery—why did eukaryotes only evolve once?; 3.1 Summary; 3.2 Introduction; 3.3 Conclusions; 3.4 References Chapter 4: A Levels-of-Selection View of Evolutionary Physiology; 4.1 Summary; 4.2 Conclusions Chapter 5: The Cell as the smallest Functional Unit of Biology/Physiology; 5.1 Summary; 5.2 In the Beginning; 5.3 The Advent of Multicellularity; 5.4 Evolution, Cellular-Style; 5.5 The Water–Land Transition and Vertebrate Evolution; 5.6 The Cellular Approach to Evolution is Predictive; 5.7 We Are Not Just in This Environment, We Are of It; 5.8 Bioethics Based on Evolutionary Ontology and Epistemology, Not Descriptive Phenotypes, and Genes; 5.9 The Theory of Everything (TOE); 5.10 CODA; 5.11 References Cited Chapter 6: Development of Tissues and Organs; 6.1 Summary; 6.2 Introduction; 6.3 Lung Alveolar Morphogenesis; 6.4 Parathyroid Hormone-related Protein (PTHrP); 6.5 Stretch-Induced Cell-Cell Interactions; 6.6 References Cited Chapter 7: When Homeostasis Fails; 7.1 Summary; 7.2 Introduction; 7.3 Peroxisome Proliferator Activated Receptor gamma as a Connection to the Evolution of the LIF; 7.4 PPARγ, Statins and TOR as Mechanisms for Homeostasis; 7.5 Homeostatic Control of What?; 7.6 Pleiotropy, the Deus ex Machina (Ghost in the Machine); 7.7 Rubik’s Cube as a Metaphor for Pleiotropic Evolution; 7.8 The Lung as the Prototypical Pleiotropic Mechanism; 7.9 The Lung as an Interactive Barrier: Homolog of the Plasma Membrane, Skin and Brain; 7.10 NKX2.1, Thyroid, Pituitary and Lung Pleiotropy; 7.11 The Phylogeny of the Thyroid; 7.12 An Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid; 7.13 A Retrospective Understanding of Evolution; 7.14 Denouement; 7.15 Conclusions Chapter 8: Wnt signaling during development; 8.1 Summary; 8.2 Introduction; 8.3 Role of Growth Factors in Alveolar Homeostasis; 8.4 The Kidney Glomerulus as a Homolog of the Lung Alveolus; 8.5 Pathologic Consequences of Failed Paracrine Signaling; 8.6 References Chapter 9: Integrated Regulation of Homeostasis- vascular, nervous, endocrine, neuroendocrine, autonomic; 9.1 Summary; 9.2 Introduction; 9.3 Water-Land transition as the catalyst for vertebrate evolution; 9.4 Parathyroid Hormone-related Protein signaling is key to understanding the evolution of the lung; 9.5 The physics of lung evolution; 9.6 Functional homology between membrane lipids and oxygenation; 9.7 Atmospheric oxygen, physiologic stress, gene duplication and lung evolution; 9.8 Duplication of the β adrenergic receptor and the glucocorticoid receptor genes; 9.9 Evolution of endothermy/homeothermy as evidence for the effect of stress on vertebrate physiologic evolution; 9.10 Hibernation as reverse evolution; 9.11 Predictive power of the cellular-molecular approach to evolution; 9.12 Conclusion; 9.13 References Cited Chapter 10: Endogenous and Exogenous Mechanisms for Healing; 10.1 Summary; 10.2 Introduction; 10.3 Endogenous Mechanisms for Healing; 10.4 Exogenous Mechanisms for Healing Using Evolutionary Principles; 10.5 References Cited Chapter 11: Systems Biology as Recapitulation of Ontogeny and Phylogeny; 11.1 Summary; 11.2 Introduction; 11.3 A Paradigm Shift in evolution; 11.4 Endothermy as ‘Proof of Principle’ for the evolution of Serial Exaptations; 11.5 Endothermy Defies Physics, Fostering Migration; 11.6 Conclusion; 11.7 References Cited Chapter 12: Terminal Addition as Physiologic Homeostasis and Regeneration, or Evolutionary Medicine; 12.1 Summary; 12.2 Introduction; 12.3 Conflicting Viewpoints; 12.4 Terminal Addition as a Perpetual Cellular Link with the Environment; 12.5 Terminal Addition as Layered Cell-Cell Signaling; 12.6 Epigenetic Impacts and Terminal Addition; 12.7 Physiologic Stress, Vascular Shear Stress, Radical Oxygen Species, and Mutation within Constraints= The Mechanism of Terminal Addition; 12.8 Homeobox Genes, Co-linearity and Terminal Addition; 12.9 The Alveolar Lipofibroblast as Terminal Addition; 12.10 The Participation of Glomerular Mesangial Cells; 12.11 PTHrP Effects on the Anterior Pituitary, Adrenal Cortex and Adrenal Medulla; 12.12 Catecholamines, Lung and Heart Biology; 12.13 Oxytocin, Endothermy and the Retina; 12.14 Central Nervous System; 12.15 Terminal Addition, ‘Reverse Evolution’ and Evolutionary Medicine; 12.16 Discussion; 12.17 Terminal Addition, the Fundament of Haeckel’s Biogenetic Law; 12.18 Somewhere Between Gene and Phenotype Lies the Process of Evolution; 12.19 Cnclusion; 12.20 References Cited Chapter 13: Phantom Limbs, Imagination and Epigenetics; 13.1 Summary; 13.2 Introduction; 13.3 Background to Phantom Limb Sensation; 13.4 Relevance of Phantom Limb Sensation to Terminal Addition; 13.5 Phantom Limb Sensation as Non-Localization; 13.6 Limbs and Hearts; 13.7 Relationship of Limbs to Bipedalism and the Evolution of Birds and Mammals; 13.8 Of Limbs and Consciousness; 13.9 Life as Fractals; 13.10 Consciousness, the Epitome of the Continuum from Inanimate to Animate; 13.11 References Cited Chapter 14: Man’s Place in the Universe; 14.1 Summary; 14.2 Introduction; 14.3 Anthropomorphisms Subvert the Biologic Imperative to Cooperate; 14.4 Euphysiology; 14.5 References Chapter 15: Evolution, Deception and Public Health; 15.1 Summary; 15.2 Part I. Deception is Deceiving: the exception that proves the rule; 15.3 Part II. Resolution of the Ambiguities by Assimilating the Deception; 15.4 Part III. Deception and Public Health; 15.5 Part IV. Prediction: Bioethics Based on First Principles of Physiology; 15.6 References Cited Afterword Index
• Edition: 1st
• Publisher Details: Chichester, West Sussex : Wiley Blackwell
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 610; Medicine; Evolution
• Languages: English
• ISBNs: 9781118838334
• Related ISBNs: 9781118838310
• Notes: Note: Description based on CIP data; resource not viewed.
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