Cancer stem cells : targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance /: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. (2016)

• Record Type: Book
• Further Information: Note: Huiping Liu, Justin D. Lathia.
• Other Names: Liu, Huiping; Lathia, Justin Durla
• Contents: Front Cover; Cancer Stem Cells; Cancer Stem Cells; Copyright; Dedication; Contents; List of Contributors; Foreword by Jane Visvader; Foreword by Stanton L. Gerson; Preface; Acknowledgments; I -- CSC Overview and Methodology; 1 -- Introduction: Cancer Stem Cells; INTRODUCTION; CANCER STEM CELL ORIGINS; Cancer Stem Cell Generation From a Single Cell of Origin; Two Models for Tumor Growth and Expansion; IDENTIFICATION OF THE CANCER STEM CELL POPULATION; Features of Cancer Stem Cell; Biomarkers for Cancer Stem Cell Identification; Key Signaling Pathways Involved in Cancer Stem Cell Maintenance MOUSE MODELS OF CANCER STEM CELL FUNCTIONPatient-Derived Xenograft Models; Germline Genetically Engineered Mouse Models; Somatic Genetically Engineered Mouse Models; Germline-Derived Allograft Models; Humanized Mouse Models; STRATEGIES FOR TARGETING CANCER STEM CELL; Protective Signaling Pathways; Immunotherapies Against Cell Surface Markers; Tumor Microenvironment-The Complicit Cells of the Cancer Stem Cell Niche; ATP-Binding Cassette Transporters: Multidrug and Redox Stress Resistance; FUTURE OF CANCER STEM CELL-DIRECTED THERAPIES; CONCLUSION; LIST OF ACRONYMS AND ABBREVIATIONS; References Reporter Systems Used for Enrichment and Analysis of Cancer Stem CellsSOX2; NANOG; OCT4; SORE6; NOTCH; TERT; s-SHIP; Alpha Fetoprotein; Transcription Factor/Lymphoid Enhancer Binding Factor; REX-1; Caveats of Using Reporters; Enrichment for Cancer Stem Cells Using Culture Media; Surface Markers Used for Enrichment and Analysis of Cancer Stem Cells; Acute Myelogenous Leukemia; Acute Lymphoblastic Leukemia; Chronic Myelogenous Leukemia; Breast Cancer; Colorectal Cancer; Liver Cancer; Pancreatic Cancer; Glioblastoma; Lung Cancer; Prostate Cancer; FUNCTIONAL ANALYSIS; Lineage Tracing In Vivo Lineage TracingGenetic Marking Methods in Transgenic Mouse Models; Lineage Tracing of Cancer Stem Cells In Vivo; Skin Papilloma; Intestinal Polyp; Medulloblastoma; Glioblastoma; Potential Utility of Genetic Marking Based on the Zygosity State; Lineage Tracing in Human Tumor Samples; In Vitro and In Vivo Tumor Formation and Clonogenic Assays; The Utility of Time-Lapse Video Microscopy for Cancer Stem Cell Studies; CONCLUSION AND FUTURE DIRECTIONS; List of Acronyms and Abbreviations; Acknowledgment; References; II -- CSCs in Representative Organ Systems 4 -- Critical Updates to the Leukemia Stem Cell Model
• Publisher Details: London : Academic Press is an imprint of Elsevier
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 616.99/407; Cancer cells; Stem cells; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Cancer cells; Stem cells; Electronic books
• Languages: English
• ISBNs: 9780128039342; 0128039345
• Related ISBNs: 0128038926; 9780128038925
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.