Designing multi-target drugs. ([2012])

• Record Type: Book
• Further Information: Note: Editors, J. Richard Morphy and C. John Harris.
• Editors: Morphy, Richard; Harris, C. John
• Contents: Simple drugs do not cure complex diseases: the need for multi-targeted drugs -- Clinical need and rationale for multi-target drugs in psychiatry -- Drug molecules and biology: network and systems aspects -- Chemoinformatic approaches to target identification -- Designing multi-target drugs: in vitro panel screening, biological fingerprinting -- Phenotypic and in vivo screening: lead discovery and drug repurposing -- Target/s identification approaches: experimental biological approaches -- Historical strategies for lead generation -- In silico lead generation approaches in multi-target drug discovery -- The challenges of multi-target lead optimization -- Combination agents versus multi-targeted agents: pros and cons -- The discovery of lapatinib -- Identification and optimization of dual PI3K/mTOR inhibitors -- Discovery of HDAC-inhibiting multi-target inhibitors -- Targeting protein-protein interactions: dual inhibitors of Bcl-2 and Bcl-xL -- Discovery of the anti-psychotic drug, ziprasidone -- The rational design of triple reuptake inhibitors for the treatment of depression -- Discovery of multi-target agents for neurological diseases via ligand design -- Designing drugs with dual activity: novel dual angiotensin II and endothelin receptor antagonists -- Ethyl urea inhibitors of the bacterial type II topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE).
• Publisher Details: Cambridge, U.K : RSC Publishing
• Publication Date: 2012
• Copyright Date: 2012
• Extent: 1 online resource (xxvii, 365 pages), illustrations
• Subjects: 615.19; Chemistry; Drugs -- Design; Drug targeting; Drug targeting; Drugs -- Design; Polypharmacy; MEDICAL -- Drug Guides; MEDICAL -- Nursing -- Pharmacology; MEDICAL -- Pharmacology; MEDICAL -- Pharmacy; Drug targeting; Drugs -- Design; Drug Design; Drug Delivery Systems; Molecular Targeted Therapy -- methods; Polypharmacy; Electronic books
• Languages: English
• ISBNs: 9781849734912; 1849734917; 9781621981435; 1621981436; 9781849733625; 1849733627
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from resource home page (ebrary, viewed November 2, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.