Drug discovery from natural products. (2012)

• Record Type: Book
• Further Information: Note: Edited by Olga Genilloud and Francisca Vicente.
• Other Names: Genilloud, Olga; Vicente, Francisca
• Contents: Preface; Introduction; Part one: Semisynthesis/ synthesis de novo of NPs: Semisynthesis approach of Ecteinascidin 743 (ET-743, Yondelis«); Chondramides and Chivosazoles - Two metabolites which interfere with the actin cytoskeleton; Class III lantibiotics - an emerging family of thioether containing peptidesMutant manufacturers; progress in enhancing the neurotrophic effects of natural FKBP ligands; Part two: Engineering NP synthetic pathways and genome mining: biosynthesis of indolocarbazole alkaloids and generation of novel derivatives by combinatorial biosynthesis; new lantibiotics from natural and engineered strains; mining microbial genomes for metabolic products of cryptic pathways; mining cyanobacterial genomes for drug-like and bioactive natural products; pigenetic approaches to natural product synthesis in fungi; Part three: New methodologies and screening technologies for the exploitation of microbial resources: novel approaches for exploiting microbial resources at Fundacion MEDINA; discovery and development of Platensimycin and Platencin; coupling chemical genomics and natural products: the discovery of parnafungins and novel antifungal leads; Part four: Novel microbial natural products and derivatives: Retapamulin-a first-in-class pleuromutilin antibiotic; natural products: new agents against MDR tuberculosis; the contribution of marine chemistry in the field of antimalarial research; epothilones as lead structures for new anticancer drugs; future challenges; Index
• Publisher Details: Cambridge, U.K : Royal Society of Chemistry
• Publication Date: 2012
• Extent: 1 online resource (xviii, 416 pages), illustrations
• Subjects: 615.19; Chemistry; Drug development; Drug development -- Case studies; Microbial products -- Industrial applications; Natural products -- Industrial applications; MEDICAL -- Drug Guides; MEDICAL -- Nursing -- Pharmacology; MEDICAL -- Pharmacology; MEDICAL -- Pharmacy; Drug Discovery; Biological Products -- therapeutic use; Drug Design; Biochemistry; Electronic books
• Languages: English
• ISBNs: 9781849734950
• Related ISBNs: 184973495X; 9781849733618; 1849733619
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.