G protein-coupled receptors : from structure to function /: from structure to function. (2011)

• Record Type: Book
• Further Information: Note: Edited by Jesus Giraldo and Jean-Philippe Pin.
• Other Names: Giraldo, Jesús; Pin, Jean-Philippe; Royal Society of Chemistry (Great Britain)
• Contents: Section I: GPCR crystal structures on the arena; Structure and mechanism of G protein signalling through crystal structures of rhodopsin; Mechanism of receptor activation through the crystal structures of the ligand-free GPCR opsin;Crystal structure of the human ¯2 adrenergic G-protein-coupled receptor; Crystal structure of a ¯ 1 adrenergic G-protein-coupled receptorCrystal structure of a human A2A adenosine receptor bound to an antagonist; Class A GPCRs: Structural analysis of the binding domain of follicle stimulating hormone receptor; Class B GPCRs: Receptor activation involving ligand binding to two receptor domains; Class C GPCRs: Structures of the extracellular regions of metabotropic glutamate receptors; Section II: GPCRs are multifaceted functional machines; G protein-coupled receptor homo- and hetero-dimerization: contribution to pharmacology and function; Detection of heteromers formed by combinations of three different receptors; Cross-talk between ionotropic and metabotropic glutamate receptors; Structural and functional basis of the crosstalk between receptors; GPCRs assemble as oligomers in the membrane, however a monomeric receptor is sufficient for G protein activation; Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors; Molecular basis of agonism revealed by fluorescence resonance energy studies; Metabotropic glutamate receptors: A paradigm of structural and functional receptor complexity; Lipid-protein interactions in GPCR-associated signaling; The role of cholesterol in GPCR signaling; Cholesterol-dependent GPCR signaling efficacy; Modulating receptor function through RAMPs: can they represent drug targets in themselves?; GRK2 Activation by Receptors; GRK2-Dependent Desensitization Downstream of G Proteins; Arrestins as multi-functional signaling adaptors; Enzyme regulation of -Arrestin-dependent signalling and trafficking of GPCRs; Section III: Modelling GPCR structure and function; Analyzing the activation mechanism of GPCRs by biophysical and computational methods; Modelling the activation mechanism of free fatty acid receptor 1; Prediction of opioid receptor oligomerization; Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from molecular dynamics simulations; Quantifying GPCR function; Mathematical modelling of metabotropic glutamate receptors function; Modelling of G-protein-coupled receptor signaling pathways; From Structure to function to drug discovery: the view-point of a medicinal chemist
• Publisher Details: Cambridge : Royal Society of Chemistry
• Publication Date: 2011
• Extent: 1 online resource (xxxv, 512 pages), illustrations (some color)
• Subjects: 572.696; Pharmacology; SCIENCE -- Life Sciences -- Biochemistry; Cell receptors -- Structure-activity relationships; G proteins -- Receptors; G proteins -- Receptors; Cell receptors -- Structure-activity relationships; Receptors, G-Protein-Coupled -- drug effects; Receptors, G-Protein-Coupled -- genetics; Drug Discovery; Receptors, G-Protein-Coupled -- physiology; Structure-Activity Relationship; Electronic books
• Languages: English
• ISBNs: 9781849733441; 1849733449
• Related ISBNs: 9781849731836; 1849731837
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.