Exploiting chemical diversity for drug discovery. (©2006)

• Record Type: Book
• Further Information: Note: Edited by Paul A. Bartlett, Michael Entzeroth.
• Other Names: Bartlett, Paul Allan, 1948-; Entzeroth, Michael; Royal Society of Chemistry (Great Britain)
• Contents: The use of polymer-assisted solution-phase synthesis and automation for the high-throughput preparation of biologically active compounds / Steven V. Ley, Mark Ladlow and Emma Vickerstaffe -- Accelerated chemistry : microwave, sonochemical, and fluorous phase techniques / Kristofer Olofsson, Peter Nilsson and Mats Larhed -- Biosynthesis of "unnatural" natural products / Yi Tang and Chaitan Khosla -- Combinatorial synthetic design : the balance of novelty and familiarity / A. Ganesan -- Compound collections : acquisition, annotation, and access / Reg Richardson -- Chemical diversity : definition and quantification / Alan C. Gibbs and Dimitris K. Agrafiotis -- Focused libraries : the evolution in strategy from large-diversity libraries to the focused library approach / Ruben Tommasi and Ivan Cornella -- Translating peptides into small molecules / Gerd Hummel, Ulrich Reineke and Ulf Reimer -- High-density plates, microarrays, microfluidics / Christof Fattinger and Gregor Dernick -- Fluorescence technologies for the investigation of chemical libraries / Eric Trinquet and Gérard Mathis -- The use of genetically engineered cell-based assays in in-vitro drug discovery / Renate Schnitzer and Wolfgang Sommergruber -- NMR-based screening : a powerful tool in fragment-based drug discovery / Jochen Klages, Murray Coles and Horst Kessler -- Screening chemical microarrays : methods and applications / Pappanaicken R. Kumaresan and Kit S. Lam -- Screen/counter-screen : early assessment of selectivity / Martyn N. Banks, Litao Zhang and John G. Houston -- Concepts for in vitro profiling : drug activity, selectivity and liability / Michael B. Bolger, Robert Fraczkiewicz, Michael Entzeroth and Boyd Steere -- In silico surrogates for in vivo properties : profiling for ADME and toxicological behavior / Michael B. Bolger, Robert Fraczkiewicz, Michael Entzeroth and Boyd Steere -- Uses of high content screening in chemical optimization / Francesca Casano, Zhuyin Li and Tina Garyantes.
• Publisher Details: Cambridge, UK : Royal Society of Chemistry
• Publication Date: 2006
• Copyright Date: 2006
• Extent: 1 online resource (xxiv, 420 pages), color illustrations
• Subjects: 615/.19; SCIENCE / Chemistry / Organic; Chemistry; Science; Combinatorial chemistry; Drugs -- Design; SCIENCE / Biotechnology; Organic chemistry; Biotechnology; Combinatorial chemistry; Drugs -- Design; Combinatorial Chemistry Techniques; Drug Design
• Languages: English
• ISBNs: 9781847552556; 1847552552
• Related ISBNs: 9780854048427; 0854048421
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.