Fragment-based drug discovery. (2015)

• Record Type: Book
• Further Information: Note: Edited by Steven Howard, Astex Pharmaceuticals, Cambridge, UK, Chris Abell, Department of Chemistry, University of Cambridge, UK.
• Editors: PhD, Howard, Steven; Abell, C
• Other Names: Royal Society of Chemistry (Great Britain), publisher.
• Contents: Machine generated contents note: ch. 1 Different Flavours of Fragments / Claudio Dagostin -- 1.1.Fragment-Based Drug Discovery -- 1.2.Different Types of Fragments -- 1.3.How We Identify Fragments -- 1.4.Selectivity -- 1.5.Applications of Fragment-Based Methods -- 1.5.1.Assigning Function -- 1.5.2.Assessing Ligandability -- 1.5.3.Speeding Up Chemical Validation -- 1.6.Targeting Protein -- Protein Interactions and Beyond -- 1.7.Targeting Oligonucleotides -- 1.8.Concluding Remarks -- References -- ch. 2 Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support / Brandon J. Bravo -- 2.1.Introduction -- 2.2.SPR Technology as Applied to FBS -- 2.3.The Basic Screening Cascade -- 2.4.Advances in Data Reduction and Active Selection in Primary Screening -- 2.4.1.Robust Drift Correction by Local Estimation -- 2.4.2.Method #1 for Hit Detection: Box Plots --
• Publisher Details: Cambridge : Royal Society of Chemistry
• Publication Date: 2015
• Extent: 1 online resource
• Subjects: 615.19; MEDICAL / Pharmacy; Drug development; Ligands (Biochemistry); SCIENCE / Chemistry / Clinical; Biochemistry; Drug development; Ligands (Biochemistry); Drug Discovery; Ligands
• Languages: English
• ISBNs: 9781782625650; 1782625658
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.