Ion channel drug discovery. (2015)

• Record Type: Book
• Further Information: Note: Edited by Brian Cox, Martin Gosling.
• Other Names: Cox, Brian contributing editor.; Gosling, Martin contributing editor.
• Contents: Ion channel drug discovery: a historical perspective / Brian Cox -- High-throughput screening / Alexander Böcker, Sabine Schaertl and Stephen D. Hess -- Automated electrophysiology in ion channel drug discovery / John Dunlop -- Structural understanding of ion channels in atomic detail / Phillip J. Stansfeld -- Voltage-gated sodium channels: structure, function, and molecular pharmacology / William A. Catterall -- AMPA receptor positive allosteric modulators: a case history / Simon E Ward -- The discovery of novel inhaled ENaC blockers for the treatment of cystic fibrosis lung disease / Catherine Howsham and Henry Danahay -- The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel / Jia Liu, Gerta Cami-Kobeci, Yiting Wang, Pissared Khuituan, Zhiwei Cai, Hongyu Li, Stephen M. Husbands and David N. Sheppard -- TRPV1 antagonism: from research to clinic / Mark S. Nash, J. Martin Verkuyl and Gurdip Bhalay -- Open access to the KCNQ channel: retigabine and second generation M-current openers / Johannes Krupp, Anthony M. Rush, Britt-Marie Swahn and Martin Main -- The therapeutic potential of hERG1 K+ channels for treating cancer and cardiac arrhythmias / John Mitcheson and Annarosa Arcangeli -- Does nature do ion channel drug discovery better than us? / Richard J. Lewis, Irina Vetter, Fernanda C. Cardoso, Marco Inserra and Glenn King -- Antibodies as ion channel modulators / Wilson Edwards and Alan D. Wickenden -- Ion channel drug discovery: future perspectives / Martin Gosling.
• Publisher Details: Cambridge : Royal Society of Chemistry
• Publication Date: 2015
• Extent: 1 online resource, illustrations
• Subjects: 615.1/9; Chemistry; Pharmaceutical chemistry; Drug development; Ion channels; Ion Channels; Drug Discovery -- methods; Drug development; Ion channels; Pharmaceutical chemistry; MEDICAL -- Pharmacology; Drug development; Ion channels; Pharmaceutical chemistry; Biochemistry; Electronic books
• Languages: English
• ISBNs: 9781849735087; 1849735085; 9781782623076; 1782623078
• Related ISBNs: 9781849731867; 1849731861
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.