New horizons in predictive toxicology : current status and application /: current status and application. (2011)

• Record Type: Book
• Further Information: Note: Alan G.E. Wilson, editor.
• Other Names: Wilson, A. G. E, 1947-; Royal Society of Chemistry (Great Britain)
• Contents: Acknowledgements -- Chapter 1. Introduction and overview / Alan G.E. Wilson -- Chapter 2. In silico tools for toxicity prediction / Mark T.D. Cronin -- Chapter 3. Development of an evaluation support system for estimating repeated-dose toxicity of chemicals based on chemical structure / Makoto Hayashi and Yuki Sakuratani -- Chapter 4. Towards a common regulatory framework for computational toxicology: current status and future perspectives / Andrew P. Worth and Aleksandra Mostrag-Szlichtyng -- Chapter 5. Information, informatics and modeling in predictive toxicology / Scott Boyer, Daniel Muthas and Nigel Greene -- Chapter 6. Cellular stress and in vitro predictive toxicology / Xuemei Liu, Jeffrey A. Kramer and Alan G.E. Wilson -- Chapter 7. In vitro genotoxicity / John J. Nicolette [and others] -- Chapter 8. Cardiac toxicity prediction: to simplify, or to integrate, that is the question / Vivek J. Kadambi, Colleen Synan and Katherine Brewer -- Chapter 9. In vitro approaches for determining liver-specific toxicity of new drug candidates / James M. McKim Jr. -- Chapter 10. Human-based in vitro experimental systems for the assessment of human-specific adverse drug effects: scientific concepts, current applications and promising approaches / Albert P. Li -- Chapter 11. Pathways of organ injury to define human response in organotypic cultures / Alison E.M. Vickers -- Chapter 12. Predicting drug-induced mitochondrial dysfunction / Sashi Nadanaciva and Yvonne Will -- Chapter 13. Non-clinical models for the evaluation of mechanisms of toxicity / Jeffrey A. Kramer -- Chapter 14. In vivo approaches to predictive toxicology using zebrafish / Michael T. Simonich, Jill A. Franzosa and Robert L. Tanguay -- Chapter 15. In vivo genetic toxicology: application to cancer risk assessment / Michael J. Schlosser and Christopher S. Farabaugh -- Chapter 16. Predicting hepatotoxicity in vivo / Timothy Maziasz -- Chapter 17. Immunotoxicity testing / Thomas T. Kawabata [and others] -- Chapter 18. In vitro developmental models and their applications in teratology research / Karen Augustine-Rauch, Julieta M. Panzica-Kelly and Cindy X. Zhang -- Chapter 19. Role and status of bridging biomarkers in predictive toxicology / William B. Mattes -- Chapter 20. Renal toxicity / K. Nasir M. Khan, Gordon C. Hard and Zaher A. Radi -- Chapter 21. Metabolism-based toxicology prediction / F. Peter Guengerich -- Chapter 22. Impact of drug transporters in the pharmacological and adverse reactions of drugs / Hiroyuki Kusuhara, Kazuya Maeda and Yuichi Sugiyama -- Chapter 23. Toxicokinetics / Dennis A. Smith -- Chapter 24. The role of computational systems biology models in toxicity testing in the 21st century: an example with predictive multi-scale models of the liver / Sudin Bhattacharya [and others] -- Chapter 25. Animal models of idiosyncratic, drug-induced liver injury / Christine M. Dugan, Patricia E. Ganey and Robert A. Roth -- Subject index.
• Publisher Details: Cambridge, U.K : Royal Society of Chemistry
• Publication Date: 2011
• Extent: 1 online resource (xxix, 702 pages), illustrations (some color)
• Subjects: 615.9; Chemistry; MEDICAL -- Toxicology; Toxicology -- Simulation methods; Toxicology -- Animal models; Toxicology -- methods; Forecasting -- methods; Models, Theoretical; Risk Assessment -- methods; Electronic books
• Languages: English
• ISBNs: 9781849733045
• Related ISBNs: 184973304X; 9781849730518; 1849730512
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.