New horizons in predictive drug metabolism and pharmacokinetics. ([2016])

• Record Type: Book
• Further Information: Note: Edited by Alan G.E. Wilson.
• Editors: Wilson, A. G. E, 1947-
• Other Names: Royal Society of Chemistry (Great Britain), issuing body.
• Contents: How physicochemical properties of drugs affect their metabolism and clearance; Role of solubility, permeability and adsorption in drug discovery in development; Models for nonspecific binding and partitioning; Cytochrome P450 mediated drug metabolism; Non-cytochrome P450 enzymes and glucuronidation; Metabolite profiling; Application of humanised and other transgenic models to predict human responses to drugs; Stem cells and drug metabolism; Chemically reactive versus stable drug metabolites: Role in adverse drug reactions; Integrating metabolism and toxicity properties; Metabolomics-based approaches to determine drug metabolite profiles; Drug-drug ineteractions: regulatory and theoretical considerations, and an industrial perspective; Drug-drug interactions: Computational approaches; Induction of hepatic cytochrome P450 enzymes: Importance in drug development and toxicity; Current status and implications of transporters: QSAR analysis method to evaluate drug-drug interactions of human bile salt export pump (ABCB11/BSEP) and prediction of intrahepatic cholestasis risk; Formulation of optimizing bioavailability; Systems pharmacology modelling; Pharmacokinetic-pharmacodynamic modelling in drug development with special reference to oncology
• Publisher Details: Cambridge, UK : Royal Society of Chemistry
• Publication Date: 2016
• Extent: 1 online resource, illustrations
• Subjects: 615.7; Drugs -- Metabolism; Pharmacokinetics; Drug development; Pharmaceutical Preparations -- metabolism; Pharmacokinetics; Drug Discovery -- methods; MEDICAL -- Pharmacology; Drug development; Drugs -- Metabolism; Pharmacokinetics; Electronic books
• Languages: English
• ISBNs: 9781782622376; 1782622373
• Related ISBNs: 1849738289; 9781849738286
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.