DNA repair in cancer therapy : molecular targets and clinical applications /: molecular targets and clinical applications. (2016)

• Record Type: Book
• Further Information: Note: Edited by Mark R. Kelley, Melissa L. Fishel.
• Editors: Kelley, Mark Richard, 1957-; Fishel, Melissa L
• Contents: 1. Overview of Current Targets and Clinical Trials: Bench to Clinic 2. MGMT a Critical DNA Repair Gene Target for Chemotherapy Resistance 3. Blockade of Base Excision Repair: Inhibition of Small Lesions Results in Big Consequences to Cancer Cells 4. PARP Inhibitors - Scientific Rationale and Clinical Development for Cancer 5. Inhibiting Selective DNA Polymerases for Therapeutic Intervention 6. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications 7. Homologous Recombination and ATM/ATR Targets 8. DNA Double Strand Break Repair by Nonhomologous End Joining and its Clinical Relevance 9. Mismatch repair 10. DNA Repair Signaling Targets 11. Personalized Cancer Medicine: DNA Repair Alterations is a Promising Predictive Marker in Cancer 12. The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies 13. Radiation DNA damage and use in cancer/therapeutics/dna repair 14. Fanconi Anemia- cross-link repair 15. Translesion DNA polymerases 16. BRCA1-BRCA2 pathway for HR and synthetic lethality 17. Synthetic lethality 18. Mechanisms of Resistance to Clinical PARP Inhibitors
• Edition: Second edition
• Publisher Details: London, United Kingdom : Academic Press is an imprint of Elsevier
• Publication Date: 2016
• Extent: 1 online resource (xix, 444 pages), color illustrations
• Subjects: 616.99/40695; Cancer -- Gene therapy; DNA repair; Cancer -- Gene therapy; DNA repair; DNA Repair; Neoplasms -- therapy; Electronic books
• Languages: English
• ISBNs: 9780128035993; 0128035994
• Related ISBNs: 9780128035825; 012803582X
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.