Bayesian designs for phase I-II clinical trials. (2016)

• Record Type: Book
• Further Information: Note: Ying Yuan, Hoang Q. Nguyen, Peter F. Thall.
• Authors: (Professor of biostatistics), Yuan, Ying; Nguyen, Hoang Q; Thall, Peter F
• Contents: Why Conduct Phase I-II Trials?; The Conventional Paradigm; The Continual Reassessment Method; Problems with Conventional Dose-Finding Methods The Phase I-II Paradigm ; Efficacy and Toxicity; Elements of Phase I-II Designs; Treatment Regimes and Clinical Outcomes; Sequentially Adaptive Decision Making; Risk-Benefit Trade-Offs; Stickiness and Adaptive Randomization; Simulation as a Design Tool Establishing Priors ; Pathological Priors; Prior Effective Sample Size; Computing Priors from Elicited Values Efficacy-Toxicity Trade-Off–Based Designs ; General Structure; Probability Model; Admissibility Criteria; Trade-off Contours; Establishing a Prior; Steps for Constructing a Design; Illustration; Sensitivity to Target Contours; Sensitivity to Prior ESS; Trinary Outcomes; Time-to-Event Outcomes Designs with Late-Onset Outcomes ; A Common Logistical Problem; Late-Onset Events as Missing Data; Probability Model; Imputation of Delayed Outcomes; Illustration Utility-Based Designs ; Assigning Utilities to Outcomes; Subjectivity of Utilities; Utility-Based Sequential Decision Making; Optimizing Radiation Dose for Brain Tumors Personalized Dose Finding ; The EffTox Design with Covariates; Biomarker-Based Dose Finding Combination Trials ; Bivariate Binary Outcomes; Bivariate Ordinal Outcomes Optimizing Molecularly Targeted Agents ; Features of Targeted Agents; One Targeted Agent; Combining Targeted and Cytotoxic Agents; Combining Two Molecularly Targeted Agents Optimizing Doses in Two Cycles ; The Two-Cycle Problem; A Two-Cycle Model; Decision Criteria; Illustration; Simulation Study Optimizing Dose and Schedule ; Schedule Dependent Effects; Trinary Outcomes; Event Times Outcomes Dealing with Dropouts ; Dropouts and Missing Efficacy; Probability Model; Dose-Finding Algorithm; Simulations Optimizing Intra-Arterial tPA ; Rapid Treatment of Stroke; Probability Model; Decision Criteria and Trial Conduct; Priors; Simulations Optimizing Sedative Dose in Preterm Infants ; Respiratory Distress Syndrome in Neonates; Clinical Outcomes and Probability Model; Prior and Likelihood; Decision Criteria; Simulations Bibliography
• Edition: 1st
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2016
• Extent: 1 online resource, illustrations (black and white)
• Subjects: 615.50724; Clinical trials -- Statistical methods; Drugs -- Testing -- Statistical methods; Bayesian statistical decision theory
• Languages: English
• ISBNs: 9781498709569
• Related ISBNs: 9781498709552
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; item not viewed.
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