Big on BK : current insights into the function of large conductance voltage- and Ca2+- activated K+ channels at the molecular, cellular and systemic levels /: current insights into the function of large conductance voltage- and Ca2+- activated K+ channels at the molecular, cellular and systemic levels. (2016)

• Record Type: Book
• Further Information: Note: Edited by Candice Contet.
• Other Names: Contet, Candice, 1979-
• Contents: Front Cover; Big on BK: Current Insights into the Function of Large Conductance Voltage- and Ca2+-Activated K+ Channels at the Molecular ... ; Copyright; Contents; Contributors; Preface; Chapter One: Biophysics of BK Channel Gating; 1. Introduction; 2. Voltage-Dependent Gating in BK Channels; 2.1. Our Current Understanding of Voltage-Dependent Channel Gating; 2.2. Operation of the Noncanonical BK Channel VSD; 2.3. Modulation of BK Voltage-Dependent Gating; 3. Ligand-Dependent Gating in BK Channels; 3.1. Ca2+-Dependent Gating; 3.2. Mg2+-Dependent Gating; 4. The BK Allosteric Gating Mechanism. 4.1. The HCA and HA Models of Allosteric BK Channel Activation4.2. Electromechanical Coupling; 4.3. Modulation of Electromechanical Coupling; 4.4. Coupling Between the Ca2+ Sensors and the Gate; 4.5. Modulation of BK Ca2+ Sensitivity; 4.6. Coupling Between Voltage and Ca2+ Sensors; 4.7. Coupling Between RCK1 and RCK2 Ca2+ Sensors; 5. The Extraordinary Conductance of BK Channels; 6. Concluding Remarks: The BK Channel as a Rebel and a Model; Acknowledgments; References; Chapter Two: Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits; 1. Introduction; 2. Discovery.
• Publisher Details: Cambridge, MA : Academic Press is an imprint of Elsevier
• Publication Date: 2016
• Extent: 1 online resource (552)
• Subjects: 571.6/4; Ion channels; SCIENCE -- Life Sciences -- Anatomy & Physiology; Ion channels; Electronic books
• Languages: English
• ISBNs: 0128036478; 9780128036471
• Related ISBNs: 0128036192; 9780128036198
• Notes: Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.