Anticancer drug development. (2001)

• Record Type: Book
• Further Information: Note: Edited by Bruce C. Baguley, David J. Kerr.
• Other Names: Baguley, Bruce C; Kerr, David J
• Contents: A brief history of cancer chemotherapy -- Novel targets in the cell cycle and cell cycle checkpoints -- Growth factor and signal transduction targets for cancer therapy -- Cell death pathways as targets for anticancer drugs -- Drug resistance pathways as targets -- Role of matrix metalloproteinases and plasminogen activators in cancer invasion and metastasis: therapeutic strategies -- Tumor vasculature as a target -- Gene-directed enzyme prodrug therapy -- Tumor antigens as targets for anticancer drug development -- Structure-based drug design and its contributions to cancer chemotherapy -- The contribution of synthetic organic chemistry to anticancer drug development -- Biosynthetic products for anticancer drug design and treatment: the bryostatins -- DNA-encoded peptide libraries and drug discovery -- Mechanism-based high-throughput screening for novel anticancer drug discovery -- Tumor cell cultures in drug development -- Screening using animal systems -- Relevance of preclinical pharmacology and toxicology to Phase I trial extrapolation techniques: relevance of animal toxicity -- Clinical trial design: incorporation of pharmacokinetic, pharmacodynamic, and pharmacogenetic principle -- Tumor imaging applications in the testing of new drugs -- Mechanistic approaches to Phase I clinical trials.
• Publisher Details: Place of publication not identified : Academic Press
• Publication Date: 2001
• Extent: 1 online resource (397 pages)
• Subjects: 616.994061; Antineoplastic agents; Drug development; Antineoplastic Agents; Drug Design; Drug Evaluation, Preclinical; Anticancéreux -- Développement; Cancer -- Chimiothérapie; Antineoplastic agents; Drug development; Arzneimittelentwicklung; Cytostatikum
• Languages: English
• ISBNs: 9780080490441; 0080490441
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.