Drug-induced ocular side effects. ([2015])

• Record Type: Book
• Further Information: Note: Frederick "Fritz" T. Fraunfelder, Frederick "Rick" W. Fraunfelder, Wiley A. Chambers ; associate editor, Bree Jensvold-Vetsch.
• Authors: Fraunfelder, Frederick T, 1934-; Fraunfelder, F. W (Frederick W.); Chambers, Wiley A
• Editors: Jensvold-Vetsch, Bree
• Contents: Front cover; Drug-Induced Ocular Side Effects; Copyright page; Table of Contents; Preface; List of Contributors; Dedication; Instructions to Users; Ocular Side Effects:; Systemic Side Effects:; WHO Classification System; 1 Principles of therapy; Pharmacodynamics; Where does the drug act?; How does a drug interact with its target?; Receptors and signal cascades; A question of quantity -- dose response; Pharmacokinetics; Barriers of the eye; Factors affecting the availability of drugs; Pharmacology Principles; 1) Do not be ignorant of the pharmacology; 2) Do not mix too many drugs. 3) Do not forget the aim of treatment4) Do not taper anti-infective drugs; 5) Do not overestimate patient compliance; 6) Do not disregard patients' warnings; 7) Do not underestimate drug interactions; 8) Do not to forget whom to treat; 9) Do not disregard alternative approaches and recommendations of how to behave in daily life; 10) Do not overlook signs of a causal relationship when discussing potential adverse events; References and Further Reading; 2 Ocular drug delivery and toxicology; Topical Ocular Administration; Basic Pharmacology and Toxicology of Topical Medications. Intraocular DistributionPreservatives; Vehicles for Topical Ocular Medication Delivery; Toxicity Responses; How to Apply Topical Ocular Medication; Applying medication to someone else (Fraunfelder 1999); Applying your own medication (Fraunfelder 1999); References and Further Reading; 3 Methods for evaluating drug-induced visual side effects; Risk; Selecting Diagnostic Tests; Frequency; Topical Administration; Order of Testing; Timing of Testing; Functional Tests; Visual acuity; Color vision; Visual fields; Contrast sensitivity testing; Electroretinography; Photostress tests. Double vision and ocular motilityPupil measurements; Corneal sensitivity; Corneal thickness; Objective Anatomical Methods; Cornea and conjunctiva; Tear film; Lens; Anterior chamber; Retina; Intraocular pressure; Number of Patients to Test; Summary; Reference; 4 The role of electrophysiology and psychophysics in ocular toxicology; Introduction; The Visual System; The retinal pigment epithelium; Functional alterations in photoreceptors; Functional alterations in cells of the inner retina (from outer plexiform to inner plexiform layer); GABA and antiseizure medications; Dopamine. Other retinal transmitters and modulatorsFunctional changes in retinal ganglion cells; The optic nerve; Carbon disulfide; Tamoxifen; Other toxic optic neuropathies; Damage to glial cells; CNS damage; The Role of Noninvasive Electrophysiology in Drug Testing; Relationship between anatomy and function; Electrooculography; Ganzfeld electroretinography; Evaluation; Multifocal electroretinography; Pattern ERG; Visually evoked cortical potential; Pupillography; Visual Electrophysiology in Drug Development; Complementary Tests; Electrophysiology; Psychophysics; Clinical examination.
• Edition: Seventh edition
• Publisher Details: London : Elsevier Saunders
• Publication Date: 2015
• Extent: 1 online resource (xi, 411 pages), illustrations (some color)
• Subjects: 615.78; Eye -- drug effects; Eye Diseases -- chemically induced; Drug-Related Side Effects and Adverse Reactions; Toxicology -- methods; Ocular toxicology -- Handbooks, manuals, etc; Ocular pharmacology -- Handbooks, manuals, etc; Drugs -- Side effects -- Handbooks, manuals, etc; Drugs -- Side effects; Ocular pharmacology; Ocular toxicology; Clinical toxicology -- Handbooks, manuals, etc; Medicine; Ocular pharmacology -- Handbooks, manuals, etc; Ocular toxicology -- Handbooks, manuals, etc; MEDICAL / Pharmacology; Handbooks and manuals; Electronic books
• Languages: English
• ISBNs: 9780323319850; 0323319858
• Related ISBNs: 9780323319843; 032331984X
• Notes: Note: Includes bibliographical references and indexes.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.