Iron metabolism : from molecular mechanisms to clinical consequences /: from molecular mechanisms to clinical consequences. (2016)

• Record Type: Book
• Further Information: Note: Robert Crichton, Université catholique de Louvain, Belgium.
• Other Names: Crichton, Robert R
• Contents: Preface 1. Solution Chemistry of Iron 1.1 Iron chemistry 1.2 Interactions of iron with dioxygen and chemistry of oxygen free radicals 1.3 Hydrolysis of iron salts 1.4 Formation and characterization of ferrihydrite 1.5 Ageing of Amorphous Ferrihydrite to more Crystalline Products 1.6 Biomineralization 1.7 Magnetite Biomineralization by Magnetotactic Bacteria References 2. The Essential Role of Iron in Biology 2.1 Introduction – iron an essential element in biology 2.2 Physical methods for the study of iron in biological systems 2.3 Classes of iron proteins 2.4 Haemoproteins 2.4.1 O2 carriers 2.4.2 Activators of molecular O2 2.4.3 Electron transporters 2.5 Iron-sulphur proteins 2.6 Non-haem, non-FeS proteins 2.6.1 Mononuclear non-haem iron proteins 2.6.2 Dinuclear non-haem iron proteins 2.7 Proteins of iron storage, transport and metabolism 2.8 The dark side of iron – ROS, RNS and NTBI References 3. Microbial Iron Uptake 3.1 Introduction 3.2 Iron uptake from Siderophores 3.2.1 Siderophores 3.2.2 Iron Transport Across the Outer Membrane in Gram-negative Bacteria 3.2.3 Transport across the periplasm and cytoplasmic membrane in Gram-negative Bacteria 3.2.4 Iron uptake by Gram-positive Bacteria References 4. Iron Acquisition by Pathogens 4.1 Introduction 4.2 Host Defense Mechanisms, Nutritional Immunity 4.3 Pathogenicity and PAIs 4.4 Pathogen Specific Iron Uptake Systems 4.4.1 Siderophores Associated with Virulence 4.4.2 Transferrin/Lactoferrin Iron Uptake 4.4.3 Haem Iron Uptake 4.4.4 Ferrous Iron Uptake 4.4.5 Ferric Citrate Uptake by Bacillus Cereus 4.5 Role of Fur, etc in virulence 4.6 Role of Pathogen ECF Sigma Factors 4.7 Fungal Pathogens References 5. Iron Uptake by Plants and Fungi 5.1 Iron Uptake by Plants 5.1.1 Introduction 5.1.2 Genome sequencing 5.1.3 Iron Acquisition by the Roots of Plants 5.1.3.1 Non-gramminaceous plants 5.1.3.2 Gramminaceous plants 5.1.4 Long distance iron transport 5.2 Iron metabolism and homeostasis in Plants 5.2.1 New Tools in Plant Research 5.2.2 Intracellular iron metabolism 5.2.3 Plant iron homeostasis 5.2.4 Diurnal regulation of iron homeostasis 5.3 Iron Uptake Metabolism and Homeostasis in Fungi 5.3.1 Introduction 5.3.2 High and low affinity iron uptake pathways 5.3.3 Iron uptake from siderophores 5.3.3 Iron metabolism and homeostasis References 6. Cellular Iron Uptake and Export in Mammals 6.1 The Transferrins 6.1.1 Introduction 6.1.2 The transferrin family 6.1.3 Structure of transferrins 6.1.4 Transferrin iron binding 6.1.5 Binding of other metals by transferrin 6.1.6 Transferrin-bound iron uptake 6.2 Cellular Iron Uptake 6.2.1 The transferrin receptors 6.2.2 The transferrin to cell cycle and iron release 6.2.3 Iron uptake from other sources 6.3 Cellular Iron Export References 7. Mammalian iron metabolism and dietary iron absorption 7.1 An overview of mammalian iron metabolism 7.1.1 Introduction 7.1.2 The way different cells handle iron 7.2 Mammalian iron absorption 7.2.1 Introduction 7.2.2 The intestinal mucosa 7.2.3 Sources of dietary iron 7.2.4 Iron loss and effects on uptake 7.3 Molecular mechanisms of mucosal iron absorption 7.3.1 Iron uptake at the apical pole 7.3.2 Iron transit through and storage in enterocytes 7.3.3 Iron efflux across the basolateral membrane 7.4.4 Regulation of iron absorption. References 8. Intracellular iron utilisation 8.1 Introduction 8.1.1 Introduction – intracellular iron pools 8.1.2 The cytosolic labile iron pool (LIP) 8.1.3 Distribution of iron in the cytosol 8.1.4 Other intracellular iron pools 8.2 Miochondrial iron metabolism 8.2.1 Mitochondrial iron uptake and storage 8.2.2 Mitochondrial Fe-S protein biogenesis 8.2.3 Maturation of cytosolic and nuclear Fe-S proteins 8.2.4 Haem biosynthesis 8.3 Haem oxygenase 8.3.1 Structure and catalytic cycle 8.3.2 Activation of haem oxygenase 1 References 9. Iron storage proteins 9.1 Introduction 9.2 The ferritin superfamilyand haemosiderins 9.2.1 The ferritin superfamily 9.2.2 Structure of mammalian ferritins 9.2.3 Plant and bacterial ferritins 8.2.4 Dps proteins and rubrerythrins 9.2.5 The mineral core 9.2.5 Haemosiderins 9.3 Iron uptake and release from ferritins and Dps proteins 9.3.1 Iron uptake in ferritins (i) entry of Fe (II) into the protein shell (ii) oxidation of Fe2+ by ferroxidase sites (iii) mineralisation of the iron core 9.3.2 Iron uptake in Dps proteins 9.3.3 Iron release from ferritin and Dps proteins References 10. Cellular and systemic iron homeostasis 10.1 Cellular iron homeostasis 10.1.1 Translational regulation of protein synthesis 10.1.2 The IRE/IRP system 10.1.3 The IREs –distribution and structure 10.1.4 Structural features of IRP1 and 2 10.1.5 The IRE/IRP system revisited – iron controls iron 10.1.6 Metabolic consequences of mutations in IREs 10.2 Systemic iron homeostasis 10.2.1 Introduction 10.2.2 Hepcidin, the key player 10.2.3 Factors which regulate hepcidin synthesis 10.2.3.1 Iron availability 10.2.3.2 Inflammatory stimuli 10.2.3.3 Erythropoietic demand 10.2.3.4 Hypoxia 10.2.3.5 Endocrine signals 10.3 Integration of iron homeostasitic systems References 11. Iron deficiency, iron overload and therapy Introduction 11.1 Iron deficiency anaemia (IDA) 11.1.1 Introduction – the size of the problem 11.1.2 Causes of IDA 11.1.3 Clinical stages and diagnosis 11.1.4 Therapeutic approaches 11.1.5 Anaemia of chronic disease (ACD), iron refractory (IRIDA) and the anaemia of chronic kidney disease (CKD) 11.2 Hereditary iron overload 11.2.1 Introduction 11.2.2 Hereditary haemochromatosis 11.2.3 Causes of hereditary haemochromatosis 11.2.4 Types of haemochromatosis 11.2.4.1 HFE-related (Type 1) haemochromatosis 11.2.4.2 Juvenile (Type 2) haemochromatosis 11.2.4.3 TfR2-related (Type 3) haemochromatosis 11.2.4.4 Ferroportin disease- Type 4 haemochromatosis 11.2.5 Therapy of hereditary haemochromatosis 11.3 Acquired Iron overload 11.3.1 Introduction –causes of acquired iron overload 11.3.2 Mechanisms of iron toxicity 11.3.3 Evaluation of iron overload 11.3.4 Chelation therapy for aquired iron overload 11.3.5 Other therapeutic approaches 12. Iron and Immunity 12.1 Introduction 12.2.1 Innate immunity 12.2 The key role of macrophages 12.2.1 Overview 12.2.2 Macrophage phenotypes 12.2.3 Microglia 12.3 Effect of iron status on phagocytic cell function 12.3.1 Iron deficiency 12.3.2 Iron overload 12.
• Edition: 4th edition
• Publisher Details: Place of publication not identified : Wiley
• Publication Date: 2016
• Extent: 1 online resource (576 pages)
• Subjects: 612.3/924; Iron -- Metabolism; Iron proteins; Iron -- Metabolism -- Disorders
• Languages: English
• ISBNs: 9781118925638
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.