A historical perspective on evidence-based immunology. ([2016])

• Record Type: Book
• Further Information: Note: Edward J. Moticka.
• Authors: Moticka, Edward J
• Contents: Front Cover; Dedication; A HISTORICAL PERSPECTIVE ON EVIDENCE-BASED IMMUNOLOGY; Copyright; Contents; Foreword; Glossary of Historical Terms; 1 -- Innate Host Defense Mechanisms and Adaptive Immun; INTRODUCTION; INNATE DEFENSE MECHANISMS; Anatomy; Cells of the Innate Host Defenses; Antimicrobial Molecules; Effector Mechanisms; Inflammation; Phagocytosis; Complement; NK Lymphocyte-mediated Cytotoxicity; Recognition of Pathogens; ADAPTIVE IMMUNE RESPONSES; Anatomy; Lymphocytes of the Adaptive Immune/ esponse; Effector Mechanisms; Recognition of Pathogens; CONCLUSION; References; TIME LINE. 2 -- Hallmarks of the Adaptive Immune ResponsesINTRODUCTION; IMMUNOLOGIC SPECIFICITY; Specificity of the Adaptive Immune Response to/ iological Pathogens; Specificity of the Response to Synthetic Pathogens; SELF-NON-SELF-DISCRIMINATION; IMMUNOLOGIC MEMORY; Early Anecdotal Evidence; Smallpox Vaccination Comes to Western Medicine; Development of Other Vaccines; Mechanisms to Explain Immunologic Memory; Duration of Immunologic Memory; Cell Proliferation in Immunologic Memory; CONCLUSION; References; TIME LINE; 3 -- Two Effector Mechanisms of the Adaptive Immune Response; INTRODUCTION; ANTIBODY. Development of SerotherapyEhrlich's Side-Chain Theory of Antibody Formation; CELL-MEDIATED IMMUNITY; Transfer of Skin Hypersensitivity Reactions; Transfer of Graft Rejection; CONCLUSION; References; TIME LINE; 4 -- The Small Lymphocyte Is the Antigen Reactive Cell; INTRODUCTION; THE SMALL LYMPHOCYTE; PASSIVE TRANSFER EXPERIMENTS; MIGRATORY PATHWAYS OF SMALL LYMPHOCYTES; DEPLETION EXPERIMENTS; IMMUNOCOMPETENCE OF THORACIC DUCT LYMPHOCYTES; MORPHOLOGICAL CHANGES OF ACTIVATED SMALL/ YMPHOCYTES; CONCLUSION; References; TIME LINE; 5 -- Lymphocytes Transform into Plasma Cells and Produce Antibodies. INTRODUCTIONCELLS AND ANTIBODIES; Composition of Antibodies; ANTIGENS AND ANTIBODIES IN/ YMPHOID ORGANS; LYMPHOCYTE-PLASMA CELL DEBATE; PASSIVE TRANSFER STUDIES; VISUALIZATION OF ANTIBODY-FORMING CELLS; Observations Using Immunofluorescent Stains; TRANSFORMATION OF SMALL LYMPHOCYTES INTO/ LASMA CELLS; CONCLUSION; References; TIME LINE; 6 -- The Clonal Selection Theory of Antibody Formation; INTRODUCTION; EARLY MODELS OF ANTIBODY FORMATION; CHALLENGES TO INSTRUCTION MODELS; PARADIGM SHIFT: FROM INSTRUCTION TO SELECTION; The Modified Enzyme Concept. The Natural Selection Hypothesis of/ ntibody FormationTHE CLONAL SELECTION THEORY; An Attempt to Disprove the Clonal Selection Theory; Extension of the Clonal Selection Theory to/ Lymphocytes; CONCLUSION; References; TIME LINE; 7 -- Plasma Cells Produce Antibody of a Single Specificity; INTRODUCTION; SINGLE CELL EXPERIMENTS: DEVELOPMENT OF THE/ ICRODROP TECHNIQUE; IMMUNOFLUORESCENT STUDIES; ANTIGEN RECEPTORS ON B LYMPHOCYTES; Cell Surface Immunoglobulin and Secreted Antibody Possess the Same Specificity; MULTIPLE MYELOMA AND THE ONE CELL: ONE/ NTIBODY CONCEPT.
• Publisher Details: Amsterdam, Netherlands : Elsevier
• Publication Date: 2016
• Extent: 1 online resource (xiv, 380 pages)
• Subjects: 616.07/9; Immunology; Immunology -- History; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Immunology; Electronic books; History
• Languages: English
• ISBNs: 9780123983756; 0123983754
• Related ISBNs: 9780123983817; 0123983819
• Notes: Note: Includes bibliographical references and index.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.