Gene therapy of the central nervous system : from bench to bedside /: from bench to bedside. (2006)

• Record Type: Book
• Further Information: Note: [edited by] Michael G. Kaplitt and Matthew J. During.
• Other Names: Kaplitt, Michael G; During, Matthew J; Ebooks Corporation.
• Contents: SECTION I. GENE TRANSFER TECHNOLOGY AND REGULATORY ISSUES; ; 1. Design and optimization of expression cassettes including promoter choice and regulatory lements; 2. Identification of Novel AAV Serotypes for Use as Vectors; 3. HSV amplicon vectors for gene delivery to the nervous system; 4. Influence of the immune system on CNS gene transfer; 5. Targeted induction of endogenous neural stem and progenitor cells: A new strategy for gene therapy of neurological disease; 6. Neurosurgical Targeting, Delivery and Infusion of Gene Therapy Agents in the Brain; 7. Gene Transfer for Neurological Disease: Agencies, Policies and Process; ; SECTION II. GENE THERAPY FOR DEGENERATIVE AND FUNCTIONAL DISORDERS; 8. Gene therapy for Parkinson’s disease; 9. Non human primate models for testing gene therapy for neurodegenerative disorders; 10. Delivery of Molecular Therapeutics into the CNS and their Distribution within the Brain; 11. Gene therapy for CNS diseases using intrabodies; 12. Gene therapy for epilepsy; ; SECTION IIII. PSYCHIATRIC AND BEHAVIORAL GENE THERAPY; 13. Genetic manipulation of learning and memory; 14. Psychiatric applications of viral vectors; 15. Use of viral vectors to influencebehavior; ; SECTION IV. GENE THERAPY FOR PAIN AND SPINAL CORD DISEASES; 16. Herpes simplex vector mediated gene transfer to the peripheralnervous system for the treatment of polyneuropathy and chronic pain; 17. Characterization of pain receptors in the spinal cord using a viral vector for spatial-temportal gene targeting; 18. Viral vector mediated gene therapy of pain; 19. VEGF, an angiogenic factor with neurotrophic activity, useful for treatment of ALS?; 20. Viral Vector Axonal Uptake and Retrograde Transport: Mechanisms and Applications; 21. Gene therapy for spinal cord injury; ; V. GENE THERAPY FOR BRAIN TUMORS AND NEUROGENETIC DISEASES; 22. Prodrug-Activation Gene Therapy; 23. Clinical trials of gene therapy for Canavan Disease; 24. Gene therapy for the late infantile form of Batten disease; 25. Molecular Imaging of Gene Therapy for Neurogenetic Diseases
• Publisher Details: Amsterdam Boston : Academic Press
• Publication Date: 2006
• Extent: 1 online resource, illustrations (some color)
• Subjects: 616.8; Nervous system -- Diseases -- Gene therapy; Central Nervous System Diseases -- therapy; Genetic Therapy; Central Nervous System Diseases -- genetics; Gene Transfer Techniques; Genetic Vectors
• Languages: English
• ISBNs: 0080454372; 9780080454375
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.