The functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria. ([2016])

• Record Type: Book
• Further Information: Note: Edited by Valentin K. Gribkoff, Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA, Elizabeth A. Jonas, Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA, J. Marie Hardwick, Department of Molecular Microbiology and Immunology and Dept. of Neurology, John Hopkins University Bloomberg Schools of Public Health and Medicine, Maryland USA.
• Editors: Gribkoff, Valentin K; Jonas, Elizabeth A; Hardwick, J. Marie
• Contents: Contributors xiv Preface xviii Section I Mitochondrial Structure and Ion Channels 1 1 Mitochondrial Permeability Transition: A Look From a Different Angle 3 ; Nickolay Brustovetsky 1.1 Regulation of Intracellular Calcium in Neurons 3 1.2 Calcium Overload and Mitochondrial Permeability Transition 4 1.3 The Mitochondrial Transition Pore 8 1.3.1 Evidence for ANT and VDAC as Components of the PTP 8 1.3.2 Alternative Hypotheses of mPTP Composition 17 Acknowledgments 22 References 22 2 The Mitochondrial Permeability Transition Pore, the c ?] Subunit of the F1FO AT P Synthase, Cellular Development, and Synaptic Efficiency 31 ; Elizabeth A. Jonas, George A. Porter, Jr., Gisela Beutner, Nelli Mnatsakanyan and Kambiz N. . Alavian 2.1 Introduction 32 2.2 Mitochondria at the Center of Cell Metabolism and Cell Death 32 2.3 Mitochondrial Inner Membrane Leak: Regulator of Metabolic Rate and Uncoupling 32 2.4 Mitochondrial Inner Membrane Channels and Exchangers are Necessary for Ca2+ Cycling and Cellular Ca2+ Dynamics 33 2.5 Mitochondrial Inner and Outer Membrane Channel Activity Regulates Ca2+ Re?]Release from Mitochondria after Buffering 34 2.6 Bcl?]2 Family Proteins Regulate Pathological Outer Mitochondrial Membrane Permeabilization (MOMP) 35 2.7 Pathological Inner Membrane Depolarization: Mitochondrial Permeability Transition 36 2.8 The Quest for an Inner Membrane Ca2+?]Sensitive Uncoupling Channel: The PT Pore 37 2.8.1 Electrophysiologic Properties of the mPTP 37 2.8.2 Characterization of a Molecular Complex Regulating the Pore 39 2.8.3 Bcl?]xL Regulates Metabolic Efficiency by Binding to the β?]Subunit of the ATP . Synthase 39 2.8.4 CypD Binds to ATP Synthase and Regulates Permeability Transition 40 2.8.5 PT Activity Regulates Cardiac Development 41 2.8.6 Regulatory Molecules Do Not Form the Pore of mPTP 42 2.9 The mPTP: A Molecular Definition 43 2.9.1 The c?]Subunit of F1FO ATP Synthase Comprises the PT Pore 43 2.9.2 The c?]Subunit of ATP Synthase Creates the High Conductance mPTP Pore 45 2.9.3 F1 Regulates Biophysical Characteristics of the Purified c?]Subunit 45 2.9.4 Structural Location of the Pore within the c?]Subunit Ring 48 2.10 Closing of the mPTP May Enhance Mitochondrial Metabolic Plasticity and Regulate Synaptic Properties in Hippocampal Neurons 49 2.11 mPTP Opening Correlates with Cell Death in Acute Ischemia, ROS Damage, . or Glutamate Excitotoxicity 49 2.12 Pro?]Apoptotic Proteolytic Cleavage Fragment of Bcl?]xL Causes Large Conductance Mitochondrial Ion Channel Activity Correlated with Hypoxic Synaptic Failure: Outer Mitochondrial Channel Membrane Activity Alone or mPTP? 51 2.13 S ynaptic Responses Decline during Long?]Term Depression in Association with Bcl?]2 Family?]Regulated Mitochondrial Channel Activity 52 2.14 S ynapse Loss During Neurodegenerative Disease May Require Mitochondrial Channel Activity 53 2.15 Conclusions 54 Acknowledgments 55 References 55 3 Mitochondrial Channels in Neurodegeneration 65; Pablo M. Peixoto, Kathleen W. . Kinnally and Evgeny Pavlov 3.1 Introduction 65 3.2 Mitochondrial Channels in the Healthy Neuron 66 3.2.1 Voltage Dependent Anion?]Selective Channel is the Food Channel 66 3.2.2 Protein Import Channels 67 3.2.3 Mitochondrial Ca2+ Channels 74 3.2.4 Mrs2 – Mg2+ Channel 75 3.2.5 Mitochondrial K+ Channels 76 3.2.6 Mitochondrial Centum Pico?]Siemens 76 3.2.7 Alkaline?]Induced Anion?]Selective Activity and Alkaline?]Induced Anion?]Selective Activity 77 3.2.8 Chloride Intracellular Channels 78 3.2.9 Alternative Ion Transport Pathways 78 3.3 Mitochondrial Channels in the Dying Cell 79 3.3.1 Apoptosis 79 3.3.2 Necrosis 80 3.4 Mitochondrial Channels in Neurodegenerative Diseases 83 3.5 Conclusions 87 References 87 Section II Control of Mitochondrial Signaling Networks 101 4 Mitochondrial Ca2+ Transport in the Control of Neuronal Functions: . Molecular and Cellular Mechanisms 103; Yuriy M. Usachev 4.1 Introduction 103 4.2 Physiological and Pharmacological Characteristics of Mitochondrial Ca2+ Transport in Neurons 106 4.3 Molecular Components of Mitochondrial Ca2+ Transport in Neurons 110 4.4 Mitochondrial Ca2+ Signaling and Neuronal Excitability 114 4.5 Mitochondrial Ca2+ Cycling in the Regulation of Synaptic Transmission 115 4.6 Mitochondrial Ca2+ Transport and the Regulation of Gene Expression in Neurons 118 4.7 Future Directions 119 Acknowledgments 120 References 120 5 A MP ?] Activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection 130; Petronela Weisová, Shona Pfeiffer and Jochen H. M. . Prehn 5.1 Introduction 130 5.1.1 AMPK Expression, Structure, and Activity Regulation in Brain 131 5.1.2 Other Roles for AMPK 135 5.1.3 AMPK in Neurological Diseases and Neurodegeneration 137 5.2 Conclusion and Future Perspectives 139 References 139 6 HDA C6: A Molecule with Multiple Functions in Neurodegenerative Diseases 146; Yan Yan and Renjie Jiao 6.1 Introduction 146 6.2 Molecular Properties of HDAC6 147 6.2.1 Classes of the HDAC Family 147 6.2.2 HDAC6 149 6.3 HDAC6 and Neurodegenerative Diseases 151 6.3.1 HDAC6 and Elimination of Proteotoxicity in Neurodegenerative Diseases 152 6.3.2 HDAC6 and Autophagic Clearance of Dysfunctional Mitochondria 156 6.4 Perspectives 158 References 159 7 Neuronal Mitochondrial Transport 166; Adam L. . Knight, Yanmin Chen, Tao Sun and Zu ?] Hang Sheng 7.1 Introduction 166 7.2 Complex Motility Patterns of Axonal Mitochondria 168 7.3 Mechanisms of Mitochondrial Transport 169 7.3.1 Kinesin Motors and Anterograde Transport 169 7.3.2 Dynein Motors and Retrograde Transport 171 7.3.3 Interplay of Opposing Motor Proteins 172 7.4 Mechanisms of Axonal Mitochondrial Anchoring 172 7.5 Regulation of Mitochondrial Transport by Synaptic Activity 173 7.6 Mitochondrial Transport and Synaptic Transmission 174 7.7 Mitochondrial Transport and Presynaptic Variability 175 7.8 Mitochondrial Transport and Axonal Branching 176 7.9 Mitochondrial Transport and Mitophagy 178 7.10 Conclusions and New Challenges 180 Acknowledgments 180 References 181 8 Mitochondria in Control of Hypothalamic Metabolic Circuits 186; Carole M. Nasrallah and Tamas L. . Horvath 8.1 Introduction 186 8.2 Yin?]Yang Relationship between Components of Hypothalamic Feeding and Satiety Circuits 187 8.3 Mitochondria and Their Dynamics 189 8.4 Metabolic Principles of Hunger and Satiety Promotion: Mitochondria in Support of Fat Versus Glucose Utilization 191 8.5 Mitochondria Dynamics and Cellular Energetics 193 8.5.1 Fission and Fusion of Mitochondria in Hypothalamic Feeding Circuits 194 8.6 Mitochondrial Dysfunction and Metabolic Disorders 196 8.7 Conclusions 197 References 197 9 Mitochondria Anchored at the Synapse 203; George A. Spirou, Dakota Jackson and Guy A. . Perkins 9.1 Introduction 203 9.2 Calibrated Positioning of Mitochondria 204 9.3 Mitochondria and Crista Structure 206 9.4 Adhering Junctions and Linkages to the Cytoskeleton 208 9.5 Linkages of the OMM to the Mitochondrial Plaque and Reticulated Membrane 210 9.6 Functions of the Organelle Complex 211 9.7 MACs and Filamentous Contacts: A Continuum of Structure? 213 Acknowledgments 214<.
• Publisher Details: Hoboken, New Jersey : Wiley
• Publication Date: 2016
• Extent: 1 online resource, illustrations (black and white, and colour)
• Subjects: 572.869; Mitochondrial pathology; Mitochondria -- Formation; Nervous system -- Diseases -- Treatment
• Languages: English
• ISBNs: 9781119017103
• Related ISBNs: 9781118709238
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.