Chemistry and biology of heparin and heparan sulfate. (2005)

• Record Type: Book
• Further Information: Note: Edited by Hari G. Garg, Robert J. Linhardt and Charles A. Hales.
• Other Names: Garg, Hari G, 1931-; Hales, Charles A, 1941-; Linhardt, Robert J
• Contents: 1. Structure and Active Domains of Heparin; ; 2. Structure and Function of Cell Associated and Pericellular Heparan Sulfate; ; 3. Methods for Structural Analysis of Heparin and Heparan Sulfate; ; ; 4. Synthetic Approach to Define Structure-Activity Relationship of Heparin and Heparan Sulfate; ; 5. Biochemical and Pharmacological Rationale for Synthetic Heparin Polysaccharides; ; ; 6. Seperation and Sequencing of Heparin and Heparan Sulfate Saccharides; ; ; 7. Biosynthesis of Heparin and Heparan Sulfate; ; 8. Remodeling of Heparan Sulfate by Extracellular Endosulfatases; ; 9. Heparan Sulfate Degradation by Heparanases; ; 10. Lysosomal Degradation of Heparin and Heparan Sulfate; ; 11. Heparin Regulation of the Complement System; ; ; 12. Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins; ; 13. Heparin Activation of Serpins; ; 14. Role of Heparin in Fibroblast Signalling; ; 15. Role of Anticoagulant Heparan Sulfate in Mammalian Reproduction; ; ; 16. Glycol-Splitting as a Device for Modulating Inhibition of Growth Factors and Heparanase by Heparin and Heparin Derivatives; ; 17. Antithrombin Activation and Designing Novel Heparin Mimics; ; ; ; 18. Influence of Heparin Chemical Modifications on Its Antiproliferative Properties; ; ; 19. Mechanisms of Cell Growth Regulation by Heparin and Heparan Sulfate; ; 20. Heparin and Low Molecular Weight Heparin in Thrombosis and Inflammation: Emerging Link; ; 21. Basic and Clinical Differences of Heparin and Low Molecular Weight Heparin; ; 22. Perlecan: An Extracellular Matrix Heparan Sulfate Proteoglycan that Regulates Key Events in Vascular Development and Disease; ; 23. Heparin and Low Molecular Weight Heparins in Clinical Cardiology; ; 24. Heparin-Induced Thrombocytopenia; ; 25. Role of Heparan Sulfate in Cancer; ; 26. Use of Heparin Preparations in Older Patients; ; 27. Advances in Low Molecular Weight Heparin Use in Pregnancy.
• Publisher Details: Boston Amsterdam London : Elsevier
• Publication Date: 2005
• Extent: 1 online resource (xviii, 774 pages), illustrations (some color)
• Subjects: 612.115; Anticoagulants (Medicine); Heparin; Anticoagulants (Medicine); Heparin; Electronic books
• Languages: English
• ISBNs: 9780080529059; 0080529054
• Related ISBNs: 0080448593; 9780080448596
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.