Computational neuroscience in epilepsy. (2011)

• Record Type: Book
• Further Information: Note: Edited by Ivan Soltesz and Kevin Staley.
• Other Names: Soltesz, Ivan; Staley, Kevin
• Contents: Contributors; ; Foreword; ; Rise of the Machines - On the Threshold of a New Era in Epilepsy Research; ; Introduction: Applications and Emerging Concepts of Computational; ; Neuroscience in Epilepsy Research; ; Part I Computational Modeling Techniques and Databases in Epilepsy Research; ; 1 Simulation of Large Networks: Technique and Progress; ; 2 The Neuron Simulation Environment in Epilepsy Research; ; 3 The CoCoDat Database: Systematically Organizing and Selecting Quantitative Data on Single Neurons and Microcircuitry; ; 4 Validating Models of Epilepsy; ; 5 Using NeuroConstruct to Develop and Modify Biologically Detailed 3D Neuronal Network Models in Health and Disease; ; 6 Computational Neuroanatomy of the Rat Hippocampus: Implications and Applications to Epilepsy; ; Part II Epilepsy and Altered Network Topology; ; 7 Modeling Circuit Alterations in Epilepsy: A Focus on Mossy Cell Loss and Mossy Fiber Sprouting in the Dentate Gyrus; ; 8 Functional Consequences of Transformed Network Topology in Hippocampal Sclerosis; ; 9 Multiple-Scale Hierarchical Connectivity of Cortical Networks Limits the Spread of Activity; ; Part III Destabilization of Neuronal Networks; ; 10 Computer Simulations of Sodium Channel Mutations that Cause Generalized Epilepsy with Febrile Seizures Plus; ; 11 Gain Modulation and Stability in Neural Networks; ; 12 Neocortical Epileptiform Activity in Neuronal Models with Biophysically Realistic Ion Channels; ; 13 Corticothalamic Feedback: A Key to Explain Absence Seizures; ; 14 Mechanisms of Graded Persistent Activity: Implications for Epilepsy; ; 15 Small Networks, Large Networks, Experiment and Theory - Can We Bring Them Together with Oscillations, Heterogeneity and Inhibition?; ; Part IV Homeostasis and Epilepsy; ; 16 Stability and Plasticity in Neuronal and Network Dynamics; ; 17 Homeostatic Plasticity and Post-Traumatic Epileptogenesis; ; Part V Mechanisms of Synchronization; ; 18 Synchronization in Hybrid Neuronal Networks; ; 19 Complex Synaptic Dynamics of GABAergic Networks of the Hippocampus; ; 20 Experimental and Theoretical Analyses of Synchrony in Feedforward Networks; ; 21 Modulation of Synchrony by Interneurons: Insights from Attentional Modulation of Responses in the Visual Cortex; ; Part VI Interictal to Ictal Transitions; ; 22 Cellular and Network Mechanisms of Oscillations Preceding and Perhaps Initiating Epileptic Discharges; ; 23 Transition to Ictal Activity in Temporal Lobe Epilepsy: Insights from Macroscopic Models; ; 24 Unified Modeling and Analysis of Primary Generalized Seizures; ; 25 A Neuronal Network Model of Corticothalamic Oscillations: The Emergence of Epileptiform Absence Seizures; ; 26 Extracellular Potassium Dynamics and Epileptogenesis; ; 27 Slow Waves Associated with Seizure Activity; ; Part VII Seizure Dynamics; ; 28 Dynamics of Epileptic Seizures during Evolution and Propagation; ; 29 Are Correlation Dimension and Lyapunov Exponents Useful Tools for Prediction of Epileptic Seizures?; ; 30 Towards a Dynamics of Seizure Mechanics; ; Part VIII Towards Computer-Aided Therapy; ; 31 Principles and Practice of Computer-Aided Drug Design as Applied to the Discovery of Antiepileptic Agents; ; 32 Computation Applied to Clinical Epilepsy and Antiepileptic Devices; ; 33 Microelectrode-based Epilepsy Therapy: A Hybrid Neural Prosthesis Incorporating Seizure Prediction and Intervention with Biomimetic Maintenance of Normal Hippocampal Function; ; Index; ; ;
• Publisher Details: Place of publication not identified : Academic Press
• Publication Date: 2011
• Extent: 1 online resource (624 pages)
• Subjects: 616.853; Epilepsy; Epilepsy -- Computer simulation; Computational neuroscience
• Languages: English
• ISBNs: 9780080559537; 0080559530
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.