Cancer drug design and discovery. (©2008)

• Record Type: Book
• Further Information: Note: Edited by Stephen Neidle.
• Other Names: Neidle, Stephen
• Contents: Modern cancer drug discovery : integrating targets, technologies and treatments / Paul Workman and Ian Collins -- Preclinical pharmacology and in vivo models / Lloyd Kelland -- Clinical trial designs for more rapid proof-of-principle and approval / Mitesh J. Borad and Daniel D. Van Hoff -- Structural biology and anticancer drug design / Dominic Tisi [and others] -- Natural product chemistry and anticancer drug discovery / Donna M. Huryn and Peter Wipf -- Pharmacokinetics and ADME optimization in drug discovery / Chad L. Stoner, Matthew D. Troutman and Caroline E. Laverty -- Temozolomide : from cytotoxic to molecularly-targeted agent / Malcolm F.G. Stevens -- Camptothecins for drug design, cancer cell death and gene targeting / Jérôme Kluza [and others] -- Targeting thymidylate synthase by antifolate drugs for the treatment of cancer / Ann L. Jackman, Martin Forster and Matthew Ng -- Targeting inactive kinases : structure as a foundation for cancer drug discovery / David J. Hosfield and Clifford D. Mol -- Cell cycle inhibitors in cancer : current status and future directions / Peter M. Fischer -- Inhibition of DNA repair as a therapeutic target / Nicola J. Curtin and Thomas Helleday -- HSP90 inhibitors : targeting the cancer chaperone for combinatorial blockade of oncogenic pathways / Swee Y. Sharp, Keith Jones and Paul Workman -- Heat shock protein-90 directed therapeutics and target validation / Edward A. Sausville -- Inhibitors of tumor angiogenesis / Adrian L. Harris and Daniele G. Generali -- The biology and oncology of RAF-ERK signaling / Victoria Emuss and Richard Marais -- Cancer drug resistance / V. Karavasilis [and others] -- Failure modes in anticancer drug discovery and development / Homer L. Pearce, Kerry L. Blanchard and Christopher A. Slapak.
• Publisher Details: New York : Academic Press
• Publication Date: 2008
• Copyright Date: 2008
• Extent: 1 online resource (xv, 473 pages, [27] pages of plates), illustrations (some color)
• Subjects: 616.994061; Antineoplastic agents -- Development; Antineoplastic agents -- Design; Cancer -- Chemotherapy; MEDICAL -- Oncology; HEALTH & FITNESS -- Diseases -- Cancer; Antineoplastic agents -- Design; Antineoplastic agents -- Development; Cancer -- Chemotherapy; Antineoplastic Agents; Drug Design; Neoplasms -- drug therapy; Electronic books
• Languages: English
• ISBNs: 9780080554952; 0080554954; 9780123694485; 0123694485
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.