Complex enzymes in microbial natural product biosynthesis. Overview articles and peptides / Part A, (2009)

• Record Type: Book
• Further Information: Note: Edited by David A. Hopwood.
• Other Names: Hopwood, D. A
• Contents: Part 1: Overview articles; ; Introduction - chemical classes of complex natural products and overview of their biosynthesis; Discovery of novel natural products; Trans-modification of intermediates on the assembly line in PKS, FAS and NRPS biosynthesis; Post-assembly line modifications, including glycosylation; Cloning and analysis of natural product pathways; In silico prediction of pathways from DNA sequence; Mass spectrometric analysis of PKS and NRPS biosynthetic intermediates; Synthetic probes for PKS and NRPS biochemistry; Directed evolution of natural products; Expression in a heterologous host; Pathway-specific and global regulation of antibiotic biosynthesis; Regulation of antibiotic production by bacterial hormones; ; Part 2: Peptides; ; A. Non-ribosomally-synthesised peptides; ; Overview of NRPSs, and mechanistic and structural studies; Siderophores; Cephamycins and clavulanic acid; Glycopeptides; Lipopeptides; Precursor Biosynthesis; ; B. Ribosomally synthesised peptides; ; Lantibiotic biosynthesis and engineering of novel compounds; Cyclic peptides from marine bacteria
• Publisher Details: Amsterdam Boston London San Diego, Calif : Elsevier Academic Press
• Publication Date: 2009
• Extent: 1 online resource (xlix, 636 pages), illustrations
• Subjects: 572/.45; Biosynthesis; Peptides -- Synthesis; Carbohydrates -- biosynthesis; Peptides; Biological Products; SCIENCE -- Life Sciences -- Biochemistry; Biosynthesis; Peptides -- Synthesis; Electronic books
• Languages: English
• ISBNs: 9780080923352; 0080923356; 9780123745880; 0123745888
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.