Emission tomography : the fundamentals of PET and SPECT /: the fundamentals of PET and SPECT. (2004)

• Record Type: Book
• Further Information: Note: [edited by] Miles N. Wernick, John N. Aarsvold.
• Other Names: Wernick, Miles N, 1962-; Aarsvold, John N
• Contents: Contributors; ; Foreword; ; Preface; ; Acknowledgments; ; 1. Imaging Science Bringing the Invisible to Light; ; I. Preamble; ; II. Introduction; ; III. Imaging Science; ; IV. Fundamental and Generic Issues of Imaging Science; ; V. Methodology and Epistemology; ; VI. A View of the Future; ; 2. Introduction to Emission Tomography; ; I. What is Emission Tomography?; ; A. The Tracer Principle; ; B. Tomography; ; II. The Making of an Emission Tomography Image; ; A. Single-Photon Emission Computed Tomography; ; B. Positron Emission Tomography; ; C. Image Reconstruction; ; D. Image Analysis; ; III. Types of Data Acquisition: Static, Dynamic, Gated, and List Mode; ; IV. Cross-Sectional Images; ; V. Radiopharmaceuticals and Their Applications; ; VI. Developments in Emission Tomography; ; 3. Evolution of Clinical Emission Tomography; ; I. Introduction; ; II. The Beginnings of Nuclear Medicine; ; A. Developments Before 1945; ; B. The Next 25 Years (1945-1970); ; III. Early Imaging Devices; ; A. Early Scanning Imagers; ; B. Early Devices Based on Gamma Cameras; ; C. Early Dedicated Positron-Emission Imagers; ; IV. Evolution of Emission Tomography and Initial Applications; ; A. Anger Camera Developments; ; B. Radiopharmaceutical Targeting Agents; ; C. Early Theoretical Developments; ; V. Clinical Applications; ; A. Brain Imaging; ; B. Thyroid Imaging and Therapy; ; C. Parathyroid Disease; ; D. Cardiac Imaging; ; E. Lung Imaging; ; F. Kidney Imaging; ; G. Bone Imaging; ; H. Reticuloendothelial System Imaging; ; I. Pancreas Imaging; ; J. Tumor Imaging; ; K. Molecular Biology Applications; ; VI. Summary; ; 4. Basic Physics of Radioisotope Imaging; ; I. Where Do the Nuclear Emissions Used in Imaging Come From?; ; A. Nuclear Constituents; ; B. Nuclear Forces and Binding Energy; ; C. Nuclear Energy Levels; ; D. Nuclear De-excitation; ; E. Nuclear Stability; ; F. Nuclear Transmutation; ; G. Nuclear Decay Probability; ; II. Relevant Modes of Nuclear Decay for Medical Radionuclide Imaging; ; A. Isomeric Transitions: Gamma-Ray Emission; ; B. Isobaric Transitions: Beta (ß) Emission; ; III. Production of Radionuclides for Imaging; ; A. The Nuclear Reactor; ; B. The Nuclear Generator; ; C. The Cyclotron; ; IV. Interactions of Nuclear Emissions in Matter; ; A. Interactions of Electrons and Positrons in Matter; ; B. Interactions of High-Energy Photons in Matter; ; V. Exploiting Radiation Interactions in Matter for Emission Imaging; ; A. Statistics of Ionization Production; ; B. Detector and Position-Sensitive Detector Basics; ; VI. Physical Factors That Determine the Fundamental Spatial Resolution Limit in Nuclear Emission Imaging; ; A. Overview of Physical Factors That Affect Emission Imaging Performance; ; B. What Is the Fundamental Spatial Resolution Limit in Radioisotope Imaging?; ; 5. Radiopharmaceuticals for Imaging the Brain; ; I. Introduction; ; II. Biochemical Processes in the Brain; ; III. New Radiopharmaceutical Development; ; A. Steps in Radiopharmaceutical Development; ; B. Criteria for Pharmaceuticals Used for In Vivo Receptor Imaging; ; IV. Neuroscience Studies; ; A. Dopaminergic System; ; B. Cholinergic System; ; C. Serotonergic System; ; D. Other Systems; ; V. Applications of Imaging Studies: Dopamine System; ; A. Distribution of Receptors, Transporters, and Enzymes; ; B. Distribution and Pharmacokinetics of Radiolabeled Drugs; ; C. Receptor Occupancy of Therapeutic Drugs; ; D. Integrity of the Presynapse; ; E. Alterations in the Levels of Endogenous Ligand Dopamine; ; F. Study of Substance Abuse Drugs; ; G. Interactions with Other Neurotransmitter Systems; ; H. Posttreatment Monitoring of the System; ; I. Etiological Studies of the System; ; J. Neurotoxicity of Drugs; ; VI. Oncology Studies; ; VII. Genomic Studies; ; A. Imaging Protein Products; ; B. Use of Antisense RNA to Image mRNA; ; VIII. Summary; ; 6. Basics of Imaging Theory and Statistics; ; I. Introduction; ; II. Linear Systems; ; A. Linear Shift-Invariant Systems; ; B. Point Spread Functions; ; C. Fourier Transform and Spectrum; ; D. System Transfer Functions; ; III. Discrete Sampling; ; A. Sampling Theorem and Aliasing; ; B. Discrete Fourier Transform; ; C. Relationship among FT, DFT, and Sampling; ; D. Interpolation; ; IV. Noise and Signal; ; A. Random Variables; ; B. Stochastic Processes; ; C. Noise Models; ; D. Power Spectrum; ; V. Filtering; ; A. Pseudoinverse; ; B. Tikhonov Regularization; ; C. Wiener Filtering; ; VI. Smoothing; ; A. Smoothing Filters; ; B. Median Filters; ; C. Smoothing Splines; ; VII. Estimation; ; A. Bayesian Parameter Estimation; ; B. Maximum Likelihood Estimation; ; C. Bias and Variance; ; VIII. Objective Assessment of Image Quality; ; A. ROC Analysis; ; B. Ideal Observer: Likelihood Ratio; ; C. Noise Equivalent Quanta and Detective Quantum Efficiency; ; D. Model Observer: (Channelized) Hoteling Observer; ; 7. Single-Photon Emission Computed Tomography; ; I. Planar Single-Photon Emission Imaging; ; A. Thyroid Studies; ; B. Ventilation/Perfusion Studies; ; C. Whole-Body Bone Studies; ; D. Other Nuclear Medicine Studies; ; II. Conventional Gamma Cameras; ; A. The Anger Camera; ; B. Principles of Collimation; ; C. Collimator Types; ; D. Scintillation Detection; ; E. Event Positioning; ; F. Photon Interactions; ; G. Camera Performance; ; III. Tomography; ; A. Tomographic Imaging; ; B. Transmission Imaging; ; C. Emission Imaging; ; D. Transmission Tomography; ; E. Emission Tomography; ; IV. Single-Photon Emission Computed Tomography Systems; ; A. System Configurations; ; B. Gantry Motions; ; C. Transmission-Source Tomography; ; D. SPECT/CT; ; E. System Performance; ; V. Tomographic Single-Photon Emission Imaging; ; A. Bone SPECT; ; B. Brain SPECT; ; C. Myocardial Perfusion SPECT; ; VI. Other Detectors and Systems; ; A. Multiple-Pi
• Publisher Details: Place of publication not identified : Academic Press
• Publication Date: 2004
• Extent: 1 online resource (596 pages)
• Subjects: 616.07/575; Tomography, Emission; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tomography, Emission
• Languages: English
• ISBNs: 9780080521879; 0080521878
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.