Mechanosensitive ion channels. Part B (©2007)

• Record Type: Book
• Further Information: Note: Edited by Owen P. Hamill.
• Other Names: Hamill, Owen P
• Contents: Front Cover; Mechanosensitive Ion Channels, Part B; Copyright Page; Contents; Contributors; Foreword; Previous Volumes in Series; Chapter 1: Mechanosensitive Ion Channels of Spiders: Mechanical Coupling, Electrophysiology, and Synaptic Modulation; I. Overview; II. Introduction; III. Types of Spider Mechanoreceptors; IV. Mechanical Coupling; V. Mechanotransduction in Slit Sensilla; A. The Ionic Selectivity of Spider Mechanosensitive Channels; B. The Location of VS-3 Mechanosensitive Channels; C. Mechanosensitive Channel Conductance, Density, and pH Sensitivity. D. Temperature Sensitivity of Mechanosensitive ChannelsE. Molecular Characterization of Spider Mechanosensitive Channels; VI. Dynamic Properties of Mechanotransduction and Action Potential Encoding; VII. Calcium Signaling During Transduction by Spider Mechanoreceptors; VIII. Synaptic Modulation of Spider Mechanoreceptors; IX. Conclusions; Acknowledgments; References; Chapter 2: Ion Channels for Mechanotransduction in the Crayfish Stretch Receptor; I. Overview; II. Introduction; III. Morphology of the SRO; IV. Functional Properties; A. General Behavior. B. Viscoelastic Properties of the Receptor MusclesC. MSCs in the Receptor Neurons; D. Macroscopic Receptor Currents in the Stretch Receptor Neurons; E. Pharmacology of the Crayfish MSCs; F. Voltage-Gated Ion Channels and the Generation of Impulse Response; G. Adaptation: A Multifactor Property; V. Summary and Discussion of Future Research Directions; Acknowledgments; References; Chapter 3: Mechanosensitive Ion Channels in Caenorhabditis elegans; I. Overview; II. Introduction; III. C. elegans Mechanosensitive Behaviors; IV. C. elegans DEG/ENaCs; A. MEC-4 and MEC-10; B. UNC-8 and DEL-1. C. UNC-105V. C. elegans TRP Ion Channels; A. OSM-9 and OCR-2; B. TRP-4; VI. Concluding Remarks; References; Chapter 4: Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom; I. Overview; II. Introduction; III. Properties and Specificity of GsMTx4; A. Biochemical and Structural; B. Biophysical and Mechanistic; C. Specificity; IV. Cellular Sites for GsMTx4; A. TRPC1 Channel; B. TRPC6 Channel; V. Potential Therapeutic Uses for GsMTx4; A. Cardiac Myocytes and Atrial Fibrillation; B. Muscular Dystrophy. C. Astrocytes and GliosisD. Neurite Growth Extension; VI. Conclusions; References; Chapter 5: Mechanosensitive Channels in Neurite Outgrowth; I. Overview; II. Introduction; III. Encoding of Guidance Cues in Axon Pathfinding; IV. Requirement of TRP Channels in Calcium-Dependent Axon Pathfinding; V. Physical Guidance Cues and Role of Mechanosensitive Ion Channels; VI. Ion Channels as Molecular Integrators; VII. Concluding Remarks; Note Added in Proof; Acknowledgments; References; Chapter 6: ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; I. Overview; II. Introduction.
• Publisher Details: San Diego, Calif : Academic Press
• Publication Date: 2007
• Copyright Date: 2007
• Extent: 1 online resource (xxi, 588 pages, [24] pages of plates), illustrations (some color)
• Subjects: 572.3; Ion channels; Membrane proteins; Biological transport, Active; Biological transport, Active; Ion channels; Membrane proteins; SCIENCE -- Life Sciences -- Biochemistry; Biological transport, Active; Ion channels; Membrane proteins; Electronic books
• Languages: English
• ISBNs: 9780080494401; 0080494404
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.