Anandamide an endogenous cannabinoid. (2009)

• Record Type: Book
• Further Information: Note: Gerald Litwack.
• Other Names: Litwack, Gerald
• Contents: Front Cover ; Vitamins and Hormones ; Copyright Page ; Contents ; Contributors ; Preface ; Chapter 1: Enzymatic Formation of Anandamide ; I. The Transacylation-Phosphodiesterase Pathway for Anandamide Formation ; II. NAT ; A. Ca-NAT ; B. iNAT ; III. NAPE-PLD; A. Structure; B. Function; C. Tissue distribution ; IV. Alternative Pathways Forming NAEs from NAPEs ; V. Conclusions; References ; Chapter 2: Organized Trafficking of Anandamide and Related Lipids; I. AEA and the Endocannabinoid System ; A. Discovery of endocannabinoids; B. AEA synthesis ; C. AEA signaling ; D. AEA degradation. E. Lipid rafts and the fate of AEA metabolites II. AEA Transport ; A. Fatty acid transporters ; B. Lipid transfer proteins ; C. Characteristics of AEA transport ; D. Proposed models for cellular AEA accumulation ; E. Implications of pharmacologically altered AEA signaling ; Acknowledgment ; References; Chapter 3: Biosynthesis of Oleamide ; I. Introduction ; II. Fatty Acid Amide Messengers: Structural Considerations ; III. Natural Occurrence of Oleamide ; IV. Biologic Actions of Oleamide ; V. Proposed Mechanisms for the Biosynthesis of Oleamide. VI. Oleamide Biosynthesis by Peptidylglycine Alpha-amidating Monooxygenase VII. Discovery of Cytochrome c as an Oleamide Synthase ; VIII. Cytochrome c also Catalyzes the Formation of Oleoylglycine and Other Long-Chain Fatty Acylamino Acids ; IX. Proposal for an Oleamide Synthesome ; X. Apoptosis: A Model for the Mechanism and Regulation of Oleamide Biosynthesis ; XI. Considerations for the Investigation of Oleamide Biosynthesis ; XII. Future Directions and Concluding Remarks ; References; Chapter 4: Anandamide Receptor Signal Transduction ; I. Introduction ; II. Cannabinoid Receptor 1. A. Regulation of cyclic AMP B. Nuclear signaling pathways ; C. CB1 Receptor-mediated regulation of ion channels ; 1. Calcium channels ; 2. Potassium channels ; 3. Neuronal plasticity ; III. Cannabinoid Receptor 2 ; A. Signaling pathways ; IV. Transient Receptor Potential Vanilloid 1 ; A. In the nervous system ; B. In vasodilation and bronchoconstriction ; V. Evidence for Additional Receptors ; A. Direct activation of ion channels ; 1. Voltage-gated Ca2+ channels ; 2. Voltage-gated sodium channels ; 3. Voltage-gated potassium channels ; 4. Task-1 ; B. 5-HT3A receptors. C. Nicotinic acetylcholine receptors D. Glycine receptors ; E. NMDA receptors ; F. Peroxisome proliferator-activated receptors ; G. Other GPCRs ; VI. Concluding Remarks ; References; Chapter 5: Is GPR55 an Anandamide Receptor? ; I. Delta9-Tetrahydrocannabinol, CB1, and CB2 Receptors ; II. Functional Evidence for Novel Cannabinoid Receptors ; III. Genomics of G Protein-Coupled Cannabinoid Receptors ; IV. The Orphan Receptor GPR55 ; A. Patent reports ; B. Pharmacology of GPR55 ; V. Endogenous Ligands for GPR55 ; A. Lysophosphatidylinositol ; B. LPI as a signaling molecule.
• Publisher Details: Amsterdam Boston : Elsevier/Academic Press
• Publication Date: 2009
• Extent: 1 online resource (xxii, 513 pages), illustrations
• Subjects: 615/.7827; Cannabinoids; Endocannabinoids; Biochemistry; Cannabinoids; MEDICAL -- Pain Medicine; MEDICAL -- Psychiatry -- Psychopharmacology; Cannabinoids; Electronic books
• Languages: English
• ISBNs: 9780080887890; 0080887899; 9780123747822; 0123747821
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.